SCAF4 and SCAF8, mRNA anti-terminator proteins
Accurate regulation of mRNA termination is required for correct gene expression. Here, we describe a role for SCAF4 and SCAF8 as anti-terminators, suppressing the use of early, alternative polyadenylation (polyA) sites. The SCAF4/8 proteins bind the hyper-phosphorylated RNAPII C-terminal repeat doma...
Main Authors: | Gregersen, LH, Mitter, R, Ugalde, AP, Nojima, T, Proudfoot, NJ, Agami, R, Stewart, A, Svejstrup, JQ |
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Format: | Journal article |
Language: | English |
Published: |
Cell Press
2019
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