p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Intact p73 function is shown to be an important determinant of cellular sensitivity to anticancer agents. Inhibition of p73 function by dominant-negative proteins or by mutant p53 abrogates apoptosis and cytotoxicity induced by these agents. A polymorphism encoding either arginine (72R) or proline (...
Main Authors: | Bergamaschi, D, Gasco, M, Hiller, L, Sullivan, A, Syed, N, Trigiante, G, Yulug, I, Merlano, M, Numico, G, Comino, A, Attard, M, Reelfs, O, Gusterson, B, Bell, A, Heath, V, Tavassoli, M, Farrell, P, Smith, P, Lu, X, Crook, T |
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Format: | Journal article |
Language: | English |
Published: |
2003
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