Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells.

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells.

Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-...

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Bibliographic Details
Main Authors: Zhang, W, Prakash, C, Sum, C, Gong, Y, Li, Y, Kwok, J, Thiessen, N, Pettersson, S, Jones, S, Knapp, S, Yang, H, Chin, K
Format: Journal article
Language:English
Published: 2013

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