Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of...

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Main Authors: Hogan, T, Nowicka, M, Cownden, D, Pearson, C, Yates, A, Seddon, B
Format: Journal article
Language:English
Published: eLife Sciences Publications 2019
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author Hogan, T
Nowicka, M
Cownden, D
Pearson, C
Yates, A
Seddon, B
author_facet Hogan, T
Nowicka, M
Cownden, D
Pearson, C
Yates, A
Seddon, B
author_sort Hogan, T
collection OXFORD
description Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of the forces generating these cells remain unclear. Here, we tracked the generation of memory CD4+ T cell subsets in mice housed in facilities differing in their 'dirtiness'. We found evidence for sequential naive to central memory to effector memory development, and confirmed that both memory subsets are heterogeneous in their rates of turnover. We also inferred that early exposure to self and environmental antigens establishes persistent memory populations at levels determined largely, although not exclusively, by the dirtiness of the environment. After the first few weeks of life, however, these populations are continuously supplemented by new memory cells at rates that are independent of environment.
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spelling oxford-uuid:30fb20bb-6aae-4776-b534-d6023955056a2022-03-26T13:05:01ZDifferential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memoryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:30fb20bb-6aae-4776-b534-d6023955056aEnglishSymplectic Elements at OxfordeLife Sciences Publications2019Hogan, TNowicka, MCownden, DPearson, CYates, ASeddon, BLaboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). However, the nature, relative importance and timing of the forces generating these cells remain unclear. Here, we tracked the generation of memory CD4+ T cell subsets in mice housed in facilities differing in their 'dirtiness'. We found evidence for sequential naive to central memory to effector memory development, and confirmed that both memory subsets are heterogeneous in their rates of turnover. We also inferred that early exposure to self and environmental antigens establishes persistent memory populations at levels determined largely, although not exclusively, by the dirtiness of the environment. After the first few weeks of life, however, these populations are continuously supplemented by new memory cells at rates that are independent of environment.
spellingShingle Hogan, T
Nowicka, M
Cownden, D
Pearson, C
Yates, A
Seddon, B
Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title_full Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title_fullStr Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title_full_unstemmed Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title_short Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory
title_sort differential impact of self and environmental antigens on the ontogeny and maintenance of cd4 t cell memory
work_keys_str_mv AT hogant differentialimpactofselfandenvironmentalantigensontheontogenyandmaintenanceofcd4tcellmemory
AT nowickam differentialimpactofselfandenvironmentalantigensontheontogenyandmaintenanceofcd4tcellmemory
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AT pearsonc differentialimpactofselfandenvironmentalantigensontheontogenyandmaintenanceofcd4tcellmemory
AT yatesa differentialimpactofselfandenvironmentalantigensontheontogenyandmaintenanceofcd4tcellmemory
AT seddonb differentialimpactofselfandenvironmentalantigensontheontogenyandmaintenanceofcd4tcellmemory