Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease
Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2017
|
| _version_ | 1797061418917298176 |
|---|---|
| author | Saenger, V Kahan, J Foltynie, T Friston, K Aziz, T Green, A van Hartevelt, T Cabral, J Stevner, A Fernandes, H Mancini, L Thornton, J Yousry, T Limousin, P Zrinzo, L Hariz, M Marques, P Sousa, N Kringelbach, M Deco, G |
| author_facet | Saenger, V Kahan, J Foltynie, T Friston, K Aziz, T Green, A van Hartevelt, T Cabral, J Stevner, A Fernandes, H Mancini, L Thornton, J Yousry, T Limousin, P Zrinzo, L Hariz, M Marques, P Sousa, N Kringelbach, M Deco, G |
| author_sort | Saenger, V |
| collection | OXFORD |
| description | Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments. |
| first_indexed | 2024-03-06T20:30:52Z |
| format | Journal article |
| id | oxford-uuid:30fd2f4b-e23e-4929-8c7c-4d6f923fdb68 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:30:52Z |
| publishDate | 2017 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:30fd2f4b-e23e-4929-8c7c-4d6f923fdb682022-03-26T13:05:05ZUncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:30fd2f4b-e23e-4929-8c7c-4d6f923fdb68EnglishSymplectic Elements at OxfordSpringer Nature2017Saenger, VKahan, JFoltynie, TFriston, KAziz, TGreen, Avan Hartevelt, TCabral, JStevner, AFernandes, HMancini, LThornton, JYousry, TLimousin, PZrinzo, LHariz, MMarques, PSousa, NKringelbach, MDeco, GDeep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance Imaging in ten patients with Parkinson's disease. Specifically, we explored the local and global impact that DBS has in creating asynchronous, stable or critical oscillatory conditions using a supercritical bifurcation model. We found that DBS shifts global brain dynamics of patients towards a Healthy regime. This effect was more pronounced in very specific brain areas such as the thalamus, globus pallidus and orbitofrontal regions of the right hemisphere (with the left hemisphere not analyzed given artifacts arising from the electrode lead). Global aspects of integration and synchronization were also rebalanced. Empirically, we found higher communicability and coherence brain measures during DBS-ON compared to DBS-OFF. Finally, using our model as a framework, artificial in silico DBS was applied to find potential alternative target areas for stimulation and whole-brain rebalancing. These results offer important insights into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, which may offer a route to more efficacious treatments. |
| spellingShingle | Saenger, V Kahan, J Foltynie, T Friston, K Aziz, T Green, A van Hartevelt, T Cabral, J Stevner, A Fernandes, H Mancini, L Thornton, J Yousry, T Limousin, P Zrinzo, L Hariz, M Marques, P Sousa, N Kringelbach, M Deco, G Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title | Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title_full | Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title_fullStr | Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title_full_unstemmed | Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title_short | Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease |
| title_sort | uncovering the underlying mechanisms and whole brain dynamics of deep brain stimulation for parkinson s disease |
| work_keys_str_mv | AT saengerv uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT kahanj uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT foltyniet uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT fristonk uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT azizt uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT greena uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT vanharteveltt uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT cabralj uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT stevnera uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT fernandesh uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT mancinil uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT thorntonj uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT yousryt uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT limousinp uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT zrinzol uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT harizm uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT marquesp uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT sousan uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT kringelbachm uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease AT decog uncoveringtheunderlyingmechanismsandwholebraindynamicsofdeepbrainstimulationforparkinsonsdisease |