Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease

Uncovering the underlying mechanisms and whole-brain dynamics of deep brain stimulation for Parkinson’s disease

Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treatment in controlling otherwise debilitating symptoms. Yet the underlying brain mechanisms are currently not well understood. Whole-brain computational modeling was used to disclose the effects of DBS during resting-s...

Full description

Bibliographic Details
Main Authors:	Saenger, V, Kahan, J, Foltynie, T, Friston, K, Aziz, T, Green, A, van Hartevelt, T, Cabral, J, Stevner, A, Fernandes, H, Mancini, L, Thornton, J, Yousry, T, Limousin, P, Zrinzo, L, Hariz, M, Marques, P, Sousa, N, Kringelbach, M, Deco, G
Format:	Journal article
Language:	English
Published:	Springer Nature 2017

Similar Items

Modulation of limbic resting-state networks by subthalamic nucleus deep brain stimulation
by: Eraifej, J, et al.
Published: (2023)

Single or multi-frequency generators in on-going brain activity: a mechanistic whole-brain model of empirical MEG data
by: Deco, G, et al.
Published: (2017)

The most relevant human brain regions for functional connectivity: Evidence for a dynamical workspace of binding nodes from whole-brain computational modelling
by: Deco, G, et al.
Published: (2016)

Controlling Parkinson's disease with adaptive deep brain stimulation.
by: Little, S, et al.
Published: (2014)

Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease
by: van Hartevelt, T, et al.
Published: (2014)

Adaptive deep brain stimulation in advanced Parkinson disease.
by: Little, S, et al.
Published: (2013)

Adaptive deep brain stimulation in advanced Parkinson disease.
by: Little, S, et al.
Published: (2013)

Bilateral adaptive deep brain stimulation is effective in Parkinson's disease
by: Brown, P, et al.
Published: (2015)

Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson’s disease
by: Oswal, A, et al.
Published: (2016)

Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease
by: Akram, H, et al.
Published: (2017)

Exploring the network dynamics underlying brain activity during rest
by: Cabral, J, et al.
Published: (2014)

Exploring the network dynamics underlying brain activity during rest.
by: Cabral, J, et al.
Published: (2014)

Exploring the network dynamics underlying brain activity during rest
by: Cabral, J, et al.
Published: (2014)

Value of subthalamic nucleus local field potentials recordings in predicting stimulation parameters for deep brain stimulation in Parkinson's disease.
by: Yoshida, F, et al.
Published: (2010)

Understanding principles of integration and segregation using whole-brain computational connectomics: implications for neuropsychiatric disorders
by: Lord, L, et al.
Published: (2017)

Entraining stepping movements of Parkinson's patients to alternating subthalamic nucleus deep brain stimulation
by: Fischer, P, et al.
Published: (2020)

Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease.
by: Litvak, V, et al.
Published: (2011)

l‐Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease
by: Akram, H, et al.
Published: (2017)

Stimulating at the right time: phase-specific deep brain stimulation
by: Cagnan, H, et al.
Published: (2017)

Adaptive deep brain stimulation for Parkinson's disease demonstrates reduced speech side effects compared to conventional stimulation in the acute setting
by: Little, S, et al.
Published: (2016)

Metastable oscillatory modes emerge from synchronization in the brain spacetime connectome
by: Cabral, J, et al.
Published: (2022)

Evidence from a rare case study for Hebbian-like changes in structural connectivity induced by long-term deep brain stimulation
by: van Hartevelt, T, et al.
Published: (2015)

Insights into brain architectures from the homological scaffolds of functional connectivity networks
by: Lord, L, et al.
Published: (2016)

Structural connectivity in schizophrenia and its impact on the dynamics of spontaneous functional networks.
by: Cabral, J, et al.
Published: (2013)

Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings.
by: Litvak, V, et al.
Published: (2012)

Brain dynamics predictive of response to psilocybin for treatment-resistant depression
by: Vohryzek, J, et al.
Published: (2024)

How structure sculpts function: Unveiling the contribution of anatomical connectivity to the brain’s spontaneous correlation structure
by: Bettinardi, R, et al.
Published: (2017)

Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgery.
by: Chen, C, et al.
Published: (2006)

Connectivity derived thalamic segmentation in deep brain stimulation for tremor
by: Akram, H, et al.
Published: (2018)

To sleep or not to sleep during deep brain stimulation surgery for Parkinson disease?
by: Aziz, T, et al.
Published: (2017)

Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep
by: Stevner, A, et al.
Published: (2019)

Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
by: Jobst, B, et al.
Published: (2017)

Alterations in brain connectivity underlying beta oscillations in Parkinsonism.
by: Moran, R, et al.
Published: (2011)

Novel fingerprinting method characterises the necessary and sufficient structural connectivity from deep brain stimulation electrodes for a successful outcome
by: Fernandes, H, et al.
Published: (2015)

Functional connectivity of the pedunculopontine nucleus and surrounding region in parkinson’s disease
by: Brown, P, et al.
Published: (2016)

A gamma band specific role of the subthalamic nucleus in switching during verbal fluency tasks in Parkinson's disease.
by: Anzak, A, et al.
Published: (2011)

Hierarchy of information processing in the brain: a novel 'intrinsic ignition' framework
by: Deco, G, et al.
Published: (2017)

Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders
by: Deco, G, et al.
Published: (2014)

Optimized beamforming for simultaneous MEG and intracranial local field potential recordings in deep brain stimulation patients.
by: Litvak, V, et al.
Published: (2010)

Rapid encoding of musical tones discovered in whole-brain connectivity
by: Bonetti, L, et al.
Published: (2021)