Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

Potassium (K (+)) channels can regulate ionic conduction through their pore by a mechanism, involving the selectivity filter, known as C-type inactivation. This process is rapid in the hERG K (+) channel and is fundamental to its physiological role. Although mutations within hERG are known to remove...

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Bibliografiske detaljer
Main Authors:	Stansfeld, P, Grottesi, A, Sands, Z, Sansom, MS, Gedeck, P, Gosling, M, Cox, B, Stanfield, P, Mitcheson, J, Sutcliffe, M
Format:	Journal article
Sprog:	English
Udgivet:	2008

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