The role of ERAP1 and HLA-B27 in ankylosing spondylitis pathogenesis
<p>HLA-B27 and ERAP1 are the two strongest predisposing genetic factors to Ankylosing Spondylitis (AS). As a key aminopeptidase in MHC class I presentation, ERAP1 potentially contributes to AS pathogenesis through altering HLA-B27 peptide presentation. In this thesis, I first studied the effec...
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| Format: | Thesis |
| Language: | English |
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2013
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