The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors.
Dopamine is considered to be the main catecholamine neurotransmitter in the human central nervous system where it controls a variety of functions (cognition, emotion, hunger and satiety, locomotor activity) in addition to endocrine system regulation. Dopamine also plays multiple roles in the periphe...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797061464221024256 |
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| author | Ribeiro-Oliveira, A Korbonits, M Grossman, AB |
| author_facet | Ribeiro-Oliveira, A Korbonits, M Grossman, AB |
| author_sort | Ribeiro-Oliveira, A |
| collection | OXFORD |
| description | Dopamine is considered to be the main catecholamine neurotransmitter in the human central nervous system where it controls a variety of functions (cognition, emotion, hunger and satiety, locomotor activity) in addition to endocrine system regulation. Dopamine also plays multiple roles in the periphery as a modulator of cardiovascular and renal function, gastrointestinal motility, and the endocrine system.1,2 It exerts its functions via binding to dopamine receptors, which belong to a family of seven transmembrane domain G protein-coupled receptors, including 5 different receptor subtypes, D 1-D5.1,2 Members of the dopamine receptor family are encoded by genes at different chromosomal loci, but show a considerable homology in their protein structure and function. Analysis of dopamine receptor structure and function has suggested the existence of two different groups of receptors: D1-like, including the D1 and D5 receptors, generally associated with a stimulatory function; and D2-like, including the D2-D4 receptors, and generally associated with inhibitory functions.1 The D1 and D 5 receptors are encoded by genes lacking introns and share 80% homology in their transmembrane domains. The D2 receptor shares a 75% homology with the D3 and 53% homology with the D4 transmembrane domains and all three receptor subtypes are encoded by genes that are interrupted by introns.1 D2-like receptors have a long third intracellular loop, typical of receptors interacting with G-inhibitory (Gi) proteins, which are able to inhibit cyclic AMP production. The third intracellular loop is the region responsible for the G-protein coupling and signal transmission while the hydrophobic transmembrane domains are responsible for the binding of dopamine agonists and antagonists.1,2 ©2008 Landes Bioscience. |
| first_indexed | 2024-03-06T20:31:32Z |
| format | Journal article |
| id | oxford-uuid:3135860a-4cea-4675-98de-c65bc69ccc70 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:31:32Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:3135860a-4cea-4675-98de-c65bc69ccc702022-03-26T13:06:32ZThe potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3135860a-4cea-4675-98de-c65bc69ccc70EnglishSymplectic Elements at Oxford2008Ribeiro-Oliveira, AKorbonits, MGrossman, ABDopamine is considered to be the main catecholamine neurotransmitter in the human central nervous system where it controls a variety of functions (cognition, emotion, hunger and satiety, locomotor activity) in addition to endocrine system regulation. Dopamine also plays multiple roles in the periphery as a modulator of cardiovascular and renal function, gastrointestinal motility, and the endocrine system.1,2 It exerts its functions via binding to dopamine receptors, which belong to a family of seven transmembrane domain G protein-coupled receptors, including 5 different receptor subtypes, D 1-D5.1,2 Members of the dopamine receptor family are encoded by genes at different chromosomal loci, but show a considerable homology in their protein structure and function. Analysis of dopamine receptor structure and function has suggested the existence of two different groups of receptors: D1-like, including the D1 and D5 receptors, generally associated with a stimulatory function; and D2-like, including the D2-D4 receptors, and generally associated with inhibitory functions.1 The D1 and D 5 receptors are encoded by genes lacking introns and share 80% homology in their transmembrane domains. The D2 receptor shares a 75% homology with the D3 and 53% homology with the D4 transmembrane domains and all three receptor subtypes are encoded by genes that are interrupted by introns.1 D2-like receptors have a long third intracellular loop, typical of receptors interacting with G-inhibitory (Gi) proteins, which are able to inhibit cyclic AMP production. The third intracellular loop is the region responsible for the G-protein coupling and signal transmission while the hydrophobic transmembrane domains are responsible for the binding of dopamine agonists and antagonists.1,2 ©2008 Landes Bioscience. |
| spellingShingle | Ribeiro-Oliveira, A Korbonits, M Grossman, AB The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title | The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title_full | The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title_fullStr | The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title_full_unstemmed | The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title_short | The potential role of D(2) dopamine receptors as a target in the management of neuroendocrine tumors. |
| title_sort | potential role of d 2 dopamine receptors as a target in the management of neuroendocrine tumors |
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