Short report: The role and significance of sputum cultures in the diagnosis of melioidosis
Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis betw...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797061491258556416 |
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| author | T'Veld, D Wuthiekanun, V Cheng, A Chierakul, W Chaowagul, W Brouwer, A White, N Day, N Peacock, S |
| author_facet | T'Veld, D Wuthiekanun, V Cheng, A Chierakul, W Chaowagul, W Brouwer, A White, N Day, N Peacock, S |
| author_sort | T'Veld, D |
| collection | OXFORD |
| description | Pneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene. |
| first_indexed | 2024-03-06T20:31:55Z |
| format | Journal article |
| id | oxford-uuid:3157543f-b623-4752-b2da-c372fa66d630 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:31:55Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:3157543f-b623-4752-b2da-c372fa66d6302022-03-26T13:07:20ZShort report: The role and significance of sputum cultures in the diagnosis of melioidosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3157543f-b623-4752-b2da-c372fa66d630EnglishSymplectic Elements at Oxford2005T'Veld, DWuthiekanun, VCheng, AChierakul, WChaowagul, WBrouwer, AWhite, NDay, NPeacock, SPneumonia is a common manifestation of melioidosis, the disease caused by Burkholderia pseudomallei. In this study, we defined the prognostic significance of a positive sputum culture. A total of 712 patients presenting to Sappasithiprasong Hospital, Ubon Ratchathani, Thailand, with melioidosis between January 1992 and December 2002 had a sputum culture performed during admission, which was positive for B. pseudomallei in 444 patients (62%). The median duration of sputum positivity was 9 days (range, 1 to 49 days). Sputum cultures were negative in 32% of patients with radiologic changes suggestive of pulmonary involvement. Overall in-hospital mortality was 48%. A positive sputum culture was associated with mortality (adjusted OR 2.8, 95% CI: 1.9, 4.0; P < 0.001). This was independent of renal disease, a prior history of melioidosis, positive blood cultures, and other potential confounders. The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene. |
| spellingShingle | T'Veld, D Wuthiekanun, V Cheng, A Chierakul, W Chaowagul, W Brouwer, A White, N Day, N Peacock, S Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title | Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title_full | Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title_fullStr | Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title_full_unstemmed | Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title_short | Short report: The role and significance of sputum cultures in the diagnosis of melioidosis |
| title_sort | short report the role and significance of sputum cultures in the diagnosis of melioidosis |
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