Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Veure altres versions (1)

The ASXL1 gene encodes a chromatin-binding protein involved in epigenetic regulation in haematopoietic cells. Loss-of-function ASXL1 mutations occur in patients with a range of myeloid malignancies and are associated with adverse outcome. We have used lentiviral-based shRNA technology to investigate...

Descripció completa

Dades bibliogràfiques
Autors principals:	Davies, C, Yip, B, Fernandez-Mercado, M, Woll, P, Agirre, X, Prosper, F, Jacobsen, SE, Wainscoat, J, Pellagatti, A, Boultwood, J
Format:	Journal article
Idioma:	English
Publicat:	2013

Ítems similars

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34+ progenitor cells
per: Davies, C, et al.
Publicat: (2013)

Frequent Mutation of the Polycomb-Associated Gene ASXL1 In Acute Myeloid Leukemia Secondary to Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
per: Fernandez-Mercado, M, et al.
Publicat: (2010)

Frequent Mutation of the Polycomb-Associated Gene ASXL1 in the Myelodysplastic Syndromes and in Acute Myeloid Leukaemia
per: Boultwood, J, et al.
Publicat: (2009)

Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia.
per: Boultwood, J, et al.
Publicat: (2010)

High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression.
per: Boultwood, J, et al.
Publicat: (2010)

High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression
per: Boultwood, J, et al.
Publicat: (2010)

Gene silencing by DNA methylation in haematological malignancies.
per: Boultwood, J, et al.
Publicat: (2007)

Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.
per: Boultwood, J, et al.
Publicat: (2013)

Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome.
per: Boultwood, J, et al.
Publicat: (2012)

5q- syndrome.
per: Boultwood, J, et al.
Publicat: (2012)

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics
per: Fernandez-Mercado, M, et al.
Publicat: (2012)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.
per: Fernandez-Mercado, M, et al.
Publicat: (2013)

A dynamic real time in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model.
per: Ruth Byrne, et al.
Publicat: (2012-01-01)

Gene expression profiling in the myelodysplastic syndromes.
per: Pellagatti, A, et al.
Publicat: (2005)

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.
per: Yip, B, et al.
Publicat: (2017)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q)
per: Pellagatti, A, et al.
Publicat: (2005)

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes
per: Marta Fernandez-Mercado, et al.
Publicat: (2013-12-01)

Gene Expression Profiling of CD34(+) Cells in Patients with Myelodysplastic Syndromes
per: Pellagatti, A, et al.
Publicat: (2008)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression.
per: Jädersten, M, et al.
Publicat: (2009)

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine
per: Rahmani, NE, et al.
Publicat: (2021)

Advances in the 5q- syndrome.
per: Boultwood, J, et al.
Publicat: (2010)

Expression profiling of CD34+cells in patients with myelodysplastic syndromes with and without a del(5q).
per: Pellagatti, A, et al.
Publicat: (2004)

Lineage studies of 5q deletions using combined immunophenotyping and fish.
per: Jaju, R, et al.
Publicat: (1999)

Combined immunophenotyping and FISH for identification of cell lineages with the 5q-abnormality
per: Jaju, R, et al.
Publicat: (1999)

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
per: Yu-Kun Xia, et al.
Publicat: (2020-07-01)

The expression of ASXL3 in prostate cancer
per: ZHANG Jinhui, et al.
Publicat: (2024-03-01)

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression
per: Martin Jädersten, et al.
Publicat: (2009-12-01)

Examining the neurodevelopmental and motor phenotypes of Bohring-Opitz syndrome (ASXL1) and Bainbridge-Ropers syndrome (ASXL3)
per: Maya C. Ayoub, et al.
Publicat: (2023-11-01)

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine
per: Nora E. Rahmani, et al.
Publicat: (2021-09-01)

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics.
per: Marta Fernandez-Mercado, et al.
Publicat: (2012-01-01)

Integrative analysis of ASXL family genes reveals ASXL2 as an immunoregulatory molecule in head and neck squamous cell carcinoma
per: Qian Liu, et al.
Publicat: (2024-12-01)

Gene expression profiling of CD34+ cells in patients with the 5q- syndrome.
per: Boultwood, J, et al.
Publicat: (2007)

Neutrophil gene expression in chronic myeloproliferative disorders.
per: Eagleton, H, et al.
Publicat: (2003)

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis
per: Takashi Izawa, et al.
Publicat: (2015-06-01)

ASXL1/2 mutations and myeloid malignancies
per: Edward A. Medina, et al.
Publicat: (2022-09-01)

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.
per: Tang, Y, et al.
Publicat: (2012)

Mast Cell-activated Bone Marrow Mesenchymal Stromal Cells Regulate Proliferation and Lineage Commitment of CD34+ Progenitor cells
per: Zoulfia eAllakhverdi, et al.
Publicat: (2013-12-01)

Molecular characterisation of ASXL1-mutant clonal haematopoiesis
per: Groom, AJ
Publicat: (2024)

Mutations of ASXL1 and TET2 in aplastic anemia
per: Jinbo Huang, et al.
Publicat: (2015-05-01)

Loss of Asxl2 leads to myeloid malignancies in mice
per: Jianping Li, et al.
Publicat: (2017-06-01)