Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex
Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of reco...
| Auteurs principaux: | , , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
American Association for the Advancement of Science
2019
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| _version_ | 1826265995638996992 |
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| author | Chiner-Oms, A Sanchez-Buso, L Corander, J Gagneux, S Harris, SR Young, D González-Candelas, F Comas, I |
| author_facet | Chiner-Oms, A Sanchez-Buso, L Corander, J Gagneux, S Harris, SR Young, D González-Candelas, F Comas, I |
| author_sort | Chiner-Oms, A |
| collection | OXFORD |
| description | Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of recombination events involving core pathogenesis functions and purifying selection on early diverging loci. We identify the phoR gene, the sensor kinase of a two-component system involved in virulence, as a key functional player subject to pervasive positive selection after the divergence of the Mycobacterium tuberculosis complex from its ancestor. Previous evidence showed that phoR mutations played a central role in the adaptation of the pathogen to different host species. Now, we show that phoR mutations have been under selection during the early spread of human tuberculosis, during later expansions, and in ongoing transmission events. Our results show that linking pathogen evolution across evolutionary and epidemiological time scales points to past and present virulence determinants. |
| first_indexed | 2024-03-06T20:32:16Z |
| format | Journal article |
| id | oxford-uuid:316fd9e4-b674-4803-a8f6-758e2c4e4a2b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:32:16Z |
| publishDate | 2019 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:316fd9e4-b674-4803-a8f6-758e2c4e4a2b2022-03-26T13:08:06ZGenomic determinants of speciation and spread of the Mycobacterium tuberculosis complexJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:316fd9e4-b674-4803-a8f6-758e2c4e4a2bEnglishSymplectic ElementsAmerican Association for the Advancement of Science2019Chiner-Oms, ASanchez-Buso, LCorander, JGagneux, SHarris, SRYoung, DGonzález-Candelas, FComas, IModels on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze the population genomics events leading to the emergence of the tuberculosis pathogen. The emergence is characterized by a combination of recombination events involving core pathogenesis functions and purifying selection on early diverging loci. We identify the phoR gene, the sensor kinase of a two-component system involved in virulence, as a key functional player subject to pervasive positive selection after the divergence of the Mycobacterium tuberculosis complex from its ancestor. Previous evidence showed that phoR mutations played a central role in the adaptation of the pathogen to different host species. Now, we show that phoR mutations have been under selection during the early spread of human tuberculosis, during later expansions, and in ongoing transmission events. Our results show that linking pathogen evolution across evolutionary and epidemiological time scales points to past and present virulence determinants. |
| spellingShingle | Chiner-Oms, A Sanchez-Buso, L Corander, J Gagneux, S Harris, SR Young, D González-Candelas, F Comas, I Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title | Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title_full | Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title_fullStr | Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title_full_unstemmed | Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title_short | Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex |
| title_sort | genomic determinants of speciation and spread of the mycobacterium tuberculosis complex |
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