Acute stress modulates genotype effects on amygdala processing in humans.
Probing gene-environment interactions that affect neural processing is crucial for understanding individual differences in behavior and disease vulnerability. Here, we tested whether the current environmental context, which affects the acute brain state, modulates genotype effects on brain function...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826266014847860736 |
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| author | Cousijn, H Rijpkema, M Qin, S van Marle, H Franke, B Hermans, E van Wingen, G Fernández, G |
| author_facet | Cousijn, H Rijpkema, M Qin, S van Marle, H Franke, B Hermans, E van Wingen, G Fernández, G |
| author_sort | Cousijn, H |
| collection | OXFORD |
| description | Probing gene-environment interactions that affect neural processing is crucial for understanding individual differences in behavior and disease vulnerability. Here, we tested whether the current environmental context, which affects the acute brain state, modulates genotype effects on brain function in humans. We manipulated the context by inducing acute psychological stress, which increases noradrenergic activity, and probed its effect on tonic activity and phasic responses in the amygdala using two MRI techniques: conventional blood oxygen level-dependent functional MRI and arterial spin labeling. We showed that only carriers of a common functional deletion in ADRA2B, the gene coding for the alpha2b-adrenoreceptor, displayed increased phasic amygdala responses under stress. Tonic activity, reflecting the perfusion of the amygdala, increased independently of genotype after stress induction. Thus, when tonic activity was heightened by stress, only deletion carriers showed increased amygdala responses. Our results demonstrate that genetic effects on brain operations can be state dependent, such that they only become apparent under specific, often environmentally controlled, conditions. |
| first_indexed | 2024-03-06T20:32:34Z |
| format | Journal article |
| id | oxford-uuid:3188f90f-72eb-42bc-bb59-ce0c68dc30a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:32:34Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:3188f90f-72eb-42bc-bb59-ce0c68dc30a42022-03-26T13:08:37ZAcute stress modulates genotype effects on amygdala processing in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3188f90f-72eb-42bc-bb59-ce0c68dc30a4EnglishSymplectic Elements at Oxford2010Cousijn, HRijpkema, MQin, Svan Marle, HFranke, BHermans, Evan Wingen, GFernández, GProbing gene-environment interactions that affect neural processing is crucial for understanding individual differences in behavior and disease vulnerability. Here, we tested whether the current environmental context, which affects the acute brain state, modulates genotype effects on brain function in humans. We manipulated the context by inducing acute psychological stress, which increases noradrenergic activity, and probed its effect on tonic activity and phasic responses in the amygdala using two MRI techniques: conventional blood oxygen level-dependent functional MRI and arterial spin labeling. We showed that only carriers of a common functional deletion in ADRA2B, the gene coding for the alpha2b-adrenoreceptor, displayed increased phasic amygdala responses under stress. Tonic activity, reflecting the perfusion of the amygdala, increased independently of genotype after stress induction. Thus, when tonic activity was heightened by stress, only deletion carriers showed increased amygdala responses. Our results demonstrate that genetic effects on brain operations can be state dependent, such that they only become apparent under specific, often environmentally controlled, conditions. |
| spellingShingle | Cousijn, H Rijpkema, M Qin, S van Marle, H Franke, B Hermans, E van Wingen, G Fernández, G Acute stress modulates genotype effects on amygdala processing in humans. |
| title | Acute stress modulates genotype effects on amygdala processing in humans. |
| title_full | Acute stress modulates genotype effects on amygdala processing in humans. |
| title_fullStr | Acute stress modulates genotype effects on amygdala processing in humans. |
| title_full_unstemmed | Acute stress modulates genotype effects on amygdala processing in humans. |
| title_short | Acute stress modulates genotype effects on amygdala processing in humans. |
| title_sort | acute stress modulates genotype effects on amygdala processing in humans |
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