Dynamics of cytotoxic T-lymphocyte exhaustion.

Dynamics of cytotoxic T-lymphocyte exhaustion.

We examine simple mathematical models to investigate the circumstances under which the dynamics of cytotoxic T-lymphocyte (CTL) activation and differentiation may result in the loss of virus specific CD8+ cells, a process known as CTL exhaustion. We distinguish between two general classes of viruses...

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Bibliographic Details
Main Authors:	Wodarz, D, Klenerman, P, Nowak, M
Format:	Journal article
Language:	English
Published:	1998

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