Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.
The minimal signalling unit for tyrosine kinase receptors is two protomers dimerized by one or more ligands. However, it is clear that maximal signalling requires the formation of larger complexes of many receptors at discrete foci on the cell surface. The biological interactions that lead to this a...
Hlavní autoři: | Harmer, N, Robinson, C, Adam, L, Ilag, L, Gallagher, J, Blundell, T |
---|---|
Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2006
|
Podobné jednotky
-
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex.
Autor: Harmer, N, a další
Vydáno: (2004) -
Myocardial protection by heparin-based coacervate of FGF10
Autor: Zhouguang Wang, a další
Vydáno: (2021-07-01) -
Crosstalk between Fibroblast Growth Factor (FGF) Receptor and Integrin through Direct Integrin Binding to FGF and Resulting Integrin-FGF-FGFR Ternary Complex Formation
Autor: Seiji Mori, a další
Vydáno: (2013-08-01) -
Comparison of FGF-8, FGF-10, FGF-Receptor 2, Androgen Receptor, Estrogen Receptor-A and SS in Healthy and Hypospadiac Children
Autor: Emaratpardaz N, a další
Vydáno: (2024-09-01) -
Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors
Autor: Mateusz Adam Krzyscik, a další
Vydáno: (2017-07-01)