TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
The T cell receptor (TCR)–peptide-MHC (pMHC) interaction is the only antigen-specific interaction during T lymphocyte activation. Recent work suggests that formation of catch bonds is characteristic of activating TCR–pMHC interactions. However, whether this binding behavior is an intrinsic feature o...
| Principais autores: | , , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
National Academy of Sciences
2019
|