TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

The T cell receptor (TCR)–peptide-MHC (pMHC) interaction is the only antigen-specific interaction during T lymphocyte activation. Recent work suggests that formation of catch bonds is characteristic of activating TCR–pMHC interactions. However, whether this binding behavior is an intrinsic feature o...

Detaylı Bibliyografya
Asıl Yazarlar:	Limozin, L, Bridge, M, Bongrand, P, Dushek, O, Van Der Merwe, P, Robert, P
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	National Academy of Sciences 2019

Benzer Materyaller

CD8 helps TCR catch slippery self pMHC
Yazar:: Dushek, O, ve diğerleri
Baskı/Yayın Bilgisi: (2018)

Microfluidic platform for characterizing TCR–pMHC interactions
Yazar:: Stockslager, Max Andrew, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Molecular dynamics simulations reveal canonical conformations in different pMHC/TCR interactions
Yazar:: Alba, J, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.
Yazar:: Boulter, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
Yazar:: Egan, JR, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
Yazar:: Egan, JR, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

172 pMHC MD simulations of Knapp et al. 2015
Yazar:: Knapp, B
Baskı/Yayın Bilgisi: (2015)

TCR binding to peptide-MHC stabilizes a flexible recognition interface.
Yazar:: Willcox, B, ve diğerleri
Baskı/Yayın Bilgisi: (1999)

Catching maladaptation before it happens
Yazar:: Schipper, ELF
Baskı/Yayın Bilgisi: (2022)

The TCR triggering puzzle.
Yazar:: Van Der Merwe, P
Baskı/Yayın Bilgisi: (2001)

CD8 co-receptor enhances T-cell activation without any effect on initial attachment
Yazar:: Robert, P, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC
Yazar:: Hoerter, John A. H., ve diğerleri
Baskı/Yayın Bilgisi: (2014)

T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.
Yazar:: Brodovitch, A, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.
Yazar:: Setterblad, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Quantifying conformational changes in the TCR:pMHC-I binding interface
Yazar:: McMaster, B, ve diğerleri
Baskı/Yayın Bilgisi: (2024)

MHC binding affects the dynamics of different T-cell receptors in different ways
Yazar:: Knapp, B, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

The kinetic-segregation model: TCR triggering and beyond.
Yazar:: Davis, S, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

TCR triggering: co-receptor-dependent or -independent?
Yazar:: Davis, S, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

The kinetic-segregation model: TCR triggering and beyond
Yazar:: Davis, S, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells
Yazar:: Patel, A, ve diğerleri
Baskı/Yayın Bilgisi: (2024)

Catch as catch can [filem]
Baskı/Yayın Bilgisi: (1973)

Catch as catch can [kesetvideo]
Baskı/Yayın Bilgisi: (1973)

Discrete LAT condensates encode antigen information from single pMHC:TCR binding events
Yazar:: McAffee, Darren B., ve diğerleri
Baskı/Yayın Bilgisi: (2023)

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.
Yazar:: Aleksic, M, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Running to catch the ball.
Yazar:: McLeod, P, ve diğerleri
Baskı/Yayın Bilgisi: (1993)

TCR triggering: Co-receptor-dependent or -independent? [2] (multiple letters)
Yazar:: Davis, S, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Description of a novel MHC class II restricted allogeneic TCR T cell therapy for acute myeloid leukaemia
Yazar:: Mickute, G
Baskı/Yayın Bilgisi: (2023)

Duration of TCR stimulation determines costimulatory requirement of T cells.
Yazar:: Kündig, T, ve diğerleri
Baskı/Yayın Bilgisi: (1996)

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.
Yazar:: Robert, P, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters.
Yazar:: Dushek, O, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
Yazar:: Burroughs, N, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Catching iguanas.
Yazar:: Sivagurunathan, Shivani
Baskı/Yayın Bilgisi: (2011)

To catch an angel /
Yazar:: 404440 Russell, Robert
Baskı/Yayın Bilgisi: ([s d)

Catch-22 /
Yazar:: 385596 Heller, Joseph
Baskı/Yayın Bilgisi: (1984)

Catch T P
Yazar:: 216199 Kreisis, Paul

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.
Yazar:: Dushek, O, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism.
Yazar:: Bachmann, M, ve diğerleri
Baskı/Yayın Bilgisi: (1998)

T-CELL ANTIGEN AND MHC RECOGNITION - MOLECULAR ANALYSIS OF HUMAN ALPHA/BETA TCR SPECIFIC FOR A TETANUS TOXIN-DERIVED PEPTIDE
Yazar:: Boitel, B, ve diğerleri
Baskı/Yayın Bilgisi: (1992)

CDR3 loop flexibility contributes to the degeneracy of TCR recognition.
Yazar:: Reiser, J, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Factors affecting TCR-repertoire diversity.
Yazar:: Wedderburn, L, ve diğerleri
Baskı/Yayın Bilgisi: (1994)