Crystal structure of an active form of human MMP-1.

Crystal structure of an active form of human MMP-1.

The extracellular matrix is a dynamic environment that constantly undergoes remodelling and degradation during vital physiological processes such as angiogenesis, wound healing, and development. Unbalanced extracellular matrix breakdown is associated with many diseases such as arthritis, cancer and...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Iyer, S, Visse, R, Nagase, H, Acharya, K
التنسيق:	Journal article
اللغة:	English
منشور في:	2006

مواد مشابهة

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
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Crystal structure of MT1-MMP hemopexin domain: identification of the dimer interface
حسب: Tochowicz, A, وآخرون
منشور في: (2010)

X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
حسب: Jozic, D, وآخرون
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Structural requirements for collagenolytic activity of matrix metalloproteinase 1 (MMP-1)
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Chain register shift in type I collagen alters MMP1 cleavage
حسب: Kuznetsova, N, وآخرون
منشور في: (2006)

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
حسب: Yamamoto, K, وآخرون
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.
حسب: Visse, R, وآخرون
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The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface.
حسب: Itoh, Y, وآخرون
منشور في: (2008)

MT1-MMP in human rheumatoid arthritis
حسب: Miller, M, وآخرون
منشور في: (2009)

Structure and function of matrix metalloproteinases and TIMPs.
حسب: Nagase, H, وآخرون
منشور في: (2006)

Kinetic characterization of new selective collagenase 3 (MMP-13) inhibitors as potential therapeutic agents in osteoarthritis
حسب: Santamaria, S, وآخرون
منشور في: (2009)

Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
حسب: Zhao, H, وآخرون
منشور في: (2004)

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) - Physiological roles and structural basis of MMP inhibition by TIMP-1
حسب: Nagase, H, وآخرون
منشور في: (2000)

Triple-helical collagen unwinding relies on cooperative binding of the catalytic and hemopexin domains of collagenase
حسب: Manka, S, وآخرون
منشور في: (2010)

The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.
حسب: Tochowicz, A, وآخرون
منشور في: (2011)

Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
حسب: Bai, S, وآخرون
منشور في: (2005)

Fluorescence quenching studies of matrix metalloproteinases (MMPs): evidence for structural rearrangement of the proMMP-2/TIMP-2 complex upon mercurial activation.
حسب: Stack, MS, وآخرون
منشور في: (1996)

Inhibitors of human collagenase, MMP1
حسب: Sergio Roberto de Andrade Leite
منشور في: (2018-04-01)

Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration.
حسب: Anilkumar, N, وآخرون
منشور في: (2005)

Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP.
حسب: Itoh, Y, وآخرون
منشور في: (2006)

Individual Timp deficiencies differentially impact pro-MMP-2 activation.
حسب: English, J, وآخرون
منشور في: (2006)

Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
حسب: Vincent ZL, وآخرون
منشور في: (2015-10-01)

Analyses of MT1-MMP activity in cells.
حسب: Evans, R, وآخرون
منشور في: (2007)

Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.
حسب: Itoh, Y, وآخرون
منشور في: (2011)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
حسب: Roa Lourdes, وآخرون
منشور في: (2008-10-01)

Cosmeceutical potentials of Curcuma mangga Val. extract in human BJ fibroblasts against MMP1, MMP3, and MMP13
حسب: Dwiyati Pujimulyani, وآخرون
منشور في: (2020-09-01)

Crystal structure of human alpha-lactalbumin at 1.7 A resolution.
حسب: Acharya, K, وآخرون
منشور في: (1991)

Distinct roles of the hemopexin and the transmembrane domains as dimer interfaces of MT1-MMP on the cell surface
حسب: Itoh, Y, وآخرون
منشور في: (2007)

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.
حسب: Lim, N, وآخرون
منشور في: (2014)

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
حسب: La Pietra, V, وآخرون
منشور في: (2012)

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.
حسب: Jonathan Baker, وآخرون
منشور في: (2018-01-01)

Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat.
حسب: Ogata, Y, وآخرون
منشور في: (2006)

RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts
حسب: Solomon A. Agere, وآخرون
منشور في: (2017-10-01)

Inhibition of apoptosis of activated hepatic stellate cells by TIMP-1 is mediated via effects on MMP inhibition: Implications for reversibility of liver fibrosis
حسب: Murphy, F, وآخرون
منشور في: (2002)

Immunoexpression of matrix metalloproteinases MMP-1, MMP-2, MMP-9 and MMP-14 in extragenital endometriosis and eutopic endometrium
حسب: Eugeniu Cazacu, وآخرون
منشور في: (2020-10-01)

Inhibition of apoptosis of activated hepatic stellate calls by TIMP-1 is mediated via effects on MMP inhibition: Implications for revesibility of liver fibrosis
حسب: Murphy, F, وآخرون
منشور في: (2002)

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
حسب: Manka, S, وآخرون
منشور في: (2012)

An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13
حسب: Seniz Inanc, وآخرون
منشور في: (2017-10-01)

Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity
حسب: Doherty, C, وآخرون
منشور في: (2016)

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1.
حسب: Ries, C, وآخرون
منشور في: (2007)