Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.

Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.

We have investigated the neuroprotective effects of combining an NMDA or AMPA receptor antagonist with a nitric oxide synthase (NOS) inhibitor in the gerbil model of global cerebral ischaemia. Ischaemia was induced by occlusion of the common carotid arteries for 5 min. (5R,10S)-(+)-5-methyl-10,11-di...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Hicks, C, Ward, M, Swettenham, J, O'Neill, M
Formato:	Journal article
Idioma:	English
Publicado em:	1999

Registros relacionados

Effect of neuronal nitric oxide synthase inhibitors and antioxidants in an experimental model of Parkinson's disease in the rat
por: Hicks, C, et al.
Publicado em: (2000)

Narrow temporal therapeutic window for NMDA antagonist protection against focal cerebral ischaemia
por: Gary K. Steinberg, et al.
Publicado em: (1995-04-01)

NMDA antagonists: their role in neuroprotection.
por: Small, D, et al.
Publicado em: (1997)

NMDA antagonists: their role in neuroprotection.
por: Small, D, et al.
Publicado em: (1997)

Neuroprotection, excitotoxicicity and nmda antagonists
por: RUBENS JOSÉ GAGLIARDI
Publicado em: (2000-06-01)

Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.
por: Xue, D, et al.
Publicado em: (1994)

DELAYED TREATMENT WITH AMPA BUT NOT NMDA GLUTAMATE ANTAGONISTS REDUCES NEOCORTICAL INFARCTION
por: Xue, D, et al.
Publicado em: (1992)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia.
por: Sutherland, B, et al.
Publicado em: (2011)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia
por: Sutherland, B, et al.
Publicado em: (2011)

AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?
por: Buchan, A, et al.
Publicado em: (1993)

POSTISCHEMIC TREATMENT WITH AMPA, BUT NOT NMDA, ANTAGONISTS PREVENTS CA1 NEURONAL INJURY
por: Li, H, et al.
Publicado em: (1992)

Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia.
por: Sutherland, B, et al.
Publicado em: (2013)

Neuroprotective effects of nicotine in two experimental models of Parkinson's disease in the rat
por: Murray, T, et al.
Publicado em: (2000)

CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
por: Menniti, F, et al.
Publicado em: (2003)

NEUROPROTECTIVE PROFILE OF FPL-15896AR, A NOVEL UNCOMPETITIVE NMDA ANTAGONIST
por: Murray, R, et al.
Publicado em: (1995)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
por: Chen, R, et al.
Publicado em: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
por: Chen, R, et al.
Publicado em: (2014)

Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity—In Vitro and In Vivo Studies
por: Gniewomir Latacz, et al.
Publicado em: (2022-01-01)

Expression of neuronal nitric oxide synthase corresponds to regions of selective vulnerability to hypoxia-ischaemia in the developing rat brain
por: Stephen M. Black, et al.
Publicado em: (1995-06-01)

Aerobic exercise repairs neurological function after cerebral ischaemia by regulating the nitric oxide
por: LEI SUN, et al.

Evaluation of the neuroprotective and antioxidant effects of Dorema aucheri extract on cerebral ischaemia-reperfusion injury in rats
por: Javad Rasouli Vani, et al.
Publicado em: (2019-01-01)

Acute Footshock Stress Induces Time-Dependent Modifications of AMPA/NMDA Protein Expression and AMPA Phosphorylation
por: Daniela Bonini, et al.
Publicado em: (2016-01-01)

Prenatal hypoxia-induced adaptation and neuroprotection that is inducible nitric oxide synthase-dependent
por: Ping Zhao, et al.
Publicado em: (2005-12-01)

Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted?
por: Buchan, A
Publicado em: (1990)

Inducible nitric oxide synthase polymorphism and fatal cerebral malaria.
por: Burgner, D, et al.
Publicado em: (1998)

Differential expression of AMPA subunits induced by NMDA intrahippocampal injection in rats
por: Helene Aparecida Fachim, et al.
Publicado em: (2016-02-01)

NMDA and Ampa receptors in synaptic membranes of cocaine and cocaine-prazosin treated rats
por: W. I. Silva, et al.
Publicado em: (2005-03-01)

Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder
por: Satoshi Suda, et al.
Publicado em: (2019-01-01)

Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
por: Corsi Massimiliano M, et al.
Publicado em: (2006-10-01)

Antiplatelet therapy in acute cerebral ischaemia.
por: Sandercock, P, et al.
Publicado em: (1999)

NMDA Receptor Antagonists for Treatment of Depression
por: Zeynep Ates-Alagoz, et al.
Publicado em: (2013-04-01)

Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
por: Sanderson Thomas M, et al.
Publicado em: (2011-07-01)

NMDA and AMPA Receptors at Synapses: Novel Targets for Tau and α-Synuclein Proteinopathies
por: Maria Italia, et al.
Publicado em: (2022-06-01)

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
por: Sun Huang, et al.
Publicado em: (2018-10-01)

Synergy of AMPA and NMDA receptor currents in dopaminergic neurons: a modeling study
por: Denis eZakharov, et al.
Publicado em: (2016-05-01)

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
por: Takahisa Hanada
Publicado em: (2020-03-01)

Mathematical modelling of cerebral ischaemia-reperfusion injury
por: Mokhtarudin, M
Publicado em: (2016)

Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens.
por: Kyle K Pitchers, et al.
Publicado em: (2012-01-01)

Neuroprotective Effect of Smilacis chinae Rhizome on NMDA-Induced Neurotoxicity In Vitro and Focal Cerebral Ischemia In Vivo
por: Ju Yeon Ban, et al.
Publicado em: (2008-01-01)

Inducible nitric oxide synthase expression is increased in the brain in fatal cerebral malaria.
por: Maneerat, Y, et al.
Publicado em: (2000)