SMAD2 is essential for TGF beta-mediated Th17 cell generation.

SMAD2 is essential for TGF beta-mediated Th17 cell generation.

TGFβ is the quintessential cytokine of T cell homeostasis. TGFβ signaling is required for the efficient differentiation and maintenance of CD4(+)FOXP3(+) T cells that inhibit immune responses. Conversely, in conjunction with the inflammatory cytokine IL-6, TGFβ promotes Th17 cell differentiation. Th...

Полное описание

Библиографические подробности
Главные авторы:	Malhotra, N, Robertson, E, Kang, J
Формат:	Journal article
Язык:	English
Опубликовано:	2010

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