Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey.
The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1990
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| _version_ | 1826266046375395328 |
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| author | O'Neill, M Dourish, C Tye, S Iversen, S |
| author_facet | O'Neill, M Dourish, C Tye, S Iversen, S |
| author_sort | O'Neill, M |
| collection | OXFORD |
| description | The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260 at doses of 100 ng/kg to 100 micrograms/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates. |
| first_indexed | 2024-03-06T20:32:59Z |
| format | Journal article |
| id | oxford-uuid:31aea7d2-1a06-4047-90f7-51da8def3703 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:32:59Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:31aea7d2-1a06-4047-90f7-51da8def37032022-03-26T13:09:30ZBlockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:31aea7d2-1a06-4047-90f7-51da8def3703EnglishSymplectic Elements at Oxford1990O'Neill, MDourish, CTye, SIversen, SThe potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260 at doses of 100 ng/kg to 100 micrograms/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates. |
| spellingShingle | O'Neill, M Dourish, C Tye, S Iversen, S Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title | Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title_full | Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title_fullStr | Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title_full_unstemmed | Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title_short | Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey. |
| title_sort | blockade of cck b receptors by l 365 260 induces analgesia in the squirrel monkey |
| work_keys_str_mv | AT oneillm blockadeofcckbreceptorsbyl365260inducesanalgesiainthesquirrelmonkey AT dourishc blockadeofcckbreceptorsbyl365260inducesanalgesiainthesquirrelmonkey AT tyes blockadeofcckbreceptorsbyl365260inducesanalgesiainthesquirrelmonkey AT iversens blockadeofcckbreceptorsbyl365260inducesanalgesiainthesquirrelmonkey |