Reliable estimation of the proportion of minor stroke due to intracerebral haemorrhage.

BACKGROUND: A previous hospital clinic-based study estimated that 3.5% of minor strokes are due to primary intracerebral haemorrhage, but the confidence intervals were wide. Moreover this figure may be an underestimate in older patients, who are less likely to be referred to secondary care, and who...

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Bibliografische gegevens
Hoofdauteurs: Lovelock, C, Redgrave, J, Briley, D, Rothwell, P
Formaat: Journal article
Taal:English
Gepubliceerd in: 2009
Omschrijving
Samenvatting:BACKGROUND: A previous hospital clinic-based study estimated that 3.5% of minor strokes are due to primary intracerebral haemorrhage, but the confidence intervals were wide. Moreover this figure may be an underestimate in older patients, who are less likely to be referred to secondary care, and who may have higher rates of intracerebral haemorrhage. Further studies are required to validate and increase the precision of this estimate and to determine any association with age, in order to plan appropriate services for minor stroke. METHOD: We determined the frequency of intracerebral haemorrhage and haemorrhagic transformation of infarction in consecutive patients presenting with minor stroke (National Institute of Health Stroke Scale<or=3) (1.2%,="" (2.1%,="" (5.1%,="" (5.4%,="" (58%="" (59%="" (oxford="" 0.5-3.0%).="" 1.0-4.6%).="" 15="" 17="" 280="" 3.2-8.0%)="" 3.3-8.7%)="" 334="" 73="" 75="" 95%="" a="" age="" age,="" aged="" an="" and="" cases="" clinic="" cohort,="" cohorts:="" computed="" confidence="" data="" early="" for="" four="" frequency="" from="" had="" haemorrhage="" haemorrhagic="" hospital-based="" hospital-clinic="" identified="" imaging.="" in="" increase="" infarction="" interval="" intracerebral="" literature="" lowest="" magnetic="" median="" men,="" meta-analysis="" minor="" no="" of="" oxford="" patients="" pooled="" population-based="" published="" resonance="" results:="" review.="" scanned="" separate="" similar="" six="" stroke="" studies="" study="" study)="" study,="" systematic="" the="" then="" there="" these="" tomography,="" transformation="" trend="" two="" vascular="" was="" we="" with="" years),="">or=85 years (0-3%). We identified only one previous study with a reliable estimate of the proportion of minor stroke due to intracerebral haemorrhage, and in a pooled analysis including 842 patients, the overall frequency of intracerebral haemorrhage was 4.8% (4.5-5.0%). CONCLUSION: We have shown that the proportion of minor stroke due to intracerebral haemorrhage was very similar in a population-based cohort and a hospital clinic-based cohort using different imaging strategies, and that the frequency is independent of age. A frequency of between 4.5 and 5.0% appears to be a reliable estimate at all ages.</or=3)>