No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826266074302119936 |
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| author | Scott, R Chu, A Grarup, N Manning, A Hivert, M Shungin, D Tönjes, A Yesupriya, A Barnes, D Bouatia-Naji, N Glazer, N Jackson, A Kutalik, Z Lagou, V Marek, D Rasmussen-Torvik, L Stringham, H Tanaka, T Aadahl, M Arking, D Bergmann, S Boerwinkle, E Bonnycastle, L Bornstein, SR Brunner, E |
| author_facet | Scott, R Chu, A Grarup, N Manning, A Hivert, M Shungin, D Tönjes, A Yesupriya, A Barnes, D Bouatia-Naji, N Glazer, N Jackson, A Kutalik, Z Lagou, V Marek, D Rasmussen-Torvik, L Stringham, H Tanaka, T Aadahl, M Arking, D Bergmann, S Boerwinkle, E Bonnycastle, L Bornstein, SR Brunner, E |
| author_sort | Scott, R |
| collection | OXFORD |
| description | Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. |
| first_indexed | 2024-03-06T20:33:25Z |
| format | Journal article |
| id | oxford-uuid:31d164b0-49b7-4dff-8630-2e676b1875ed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:33:25Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:31d164b0-49b7-4dff-8630-2e676b1875ed2022-03-26T13:10:20ZNo interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:31d164b0-49b7-4dff-8630-2e676b1875edEnglishSymplectic Elements at Oxford2012Scott, RChu, AGrarup, NManning, AHivert, MShungin, DTönjes, AYesupriya, ABarnes, DBouatia-Naji, NGlazer, NJackson, AKutalik, ZLagou, VMarek, DRasmussen-Torvik, LStringham, HTanaka, TAadahl, MArking, DBergmann, SBoerwinkle, EBonnycastle, LBornstein, SRBrunner, EGene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. |
| spellingShingle | Scott, R Chu, A Grarup, N Manning, A Hivert, M Shungin, D Tönjes, A Yesupriya, A Barnes, D Bouatia-Naji, N Glazer, N Jackson, A Kutalik, Z Lagou, V Marek, D Rasmussen-Torvik, L Stringham, H Tanaka, T Aadahl, M Arking, D Bergmann, S Boerwinkle, E Bonnycastle, L Bornstein, SR Brunner, E No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title_full | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title_fullStr | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title_full_unstemmed | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title_short | No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. |
| title_sort | no interactions between previously associated 2 hour glucose gene variants and physical activity or bmi on 2 hour glucose levels |
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