Controlling size and size distribution of electrohydrodynamically prepared microbubbles
There are several methods for producing commercial quantities of coated microbubbles with diameters <10 μm and a low polydispersivity index for use as ultrasound contrast agents, drug and gene delivery vehicles. Co-axial electrohydrodynamic microbubbling is a recently developed method which c...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826266076207382528 |
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| author | Farook, U Stride, E Edirisinghe, M |
| author_facet | Farook, U Stride, E Edirisinghe, M |
| author_sort | Farook, U |
| collection | OXFORD |
| description | There are several methods for producing commercial quantities of coated microbubbles with diameters <10 μm and a low polydispersivity index for use as ultrasound contrast agents, drug and gene delivery vehicles. Co-axial electrohydrodynamic microbubbling is a recently developed method which can generate microbubbles at a high rate. In this method, two capillary needles are concentrically aligned and subjected to a potential difference applied between the needles and a ground electrode with a stream of gas pushed through the inner needle and a stream of liquid through the outer so that a two-phase jet is formed at the outlet. The jet breaks up into microbubbles which are collected in a suitable liquid. In this work, co-axial electrohydrodynamic microbubbling was used to prepare microbubbles from a phospholipid suspension containing 2 wt-% Tween 80, a surfactant. Microbubbling was carried out under different electrical fields and air/liquid flowrates in order to prepare microbubbles with a low polydispersivity index. At the ambient temperature, the microbubbles collected in distilled water had a mean diameter of ∼5 μm with a polydispersivity index of ∼9% and were stable for >18 h. © 2009 Institute of Materials, Minerals and Mining. |
| first_indexed | 2024-03-06T20:33:27Z |
| format | Journal article |
| id | oxford-uuid:31d38715-e72c-4ab7-880c-fe82ae7d7a03 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:33:27Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:31d38715-e72c-4ab7-880c-fe82ae7d7a032022-03-26T13:10:20ZControlling size and size distribution of electrohydrodynamically prepared microbubblesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:31d38715-e72c-4ab7-880c-fe82ae7d7a03EnglishSymplectic Elements at Oxford2009Farook, UStride, EEdirisinghe, MThere are several methods for producing commercial quantities of coated microbubbles with diameters <10 μm and a low polydispersivity index for use as ultrasound contrast agents, drug and gene delivery vehicles. Co-axial electrohydrodynamic microbubbling is a recently developed method which can generate microbubbles at a high rate. In this method, two capillary needles are concentrically aligned and subjected to a potential difference applied between the needles and a ground electrode with a stream of gas pushed through the inner needle and a stream of liquid through the outer so that a two-phase jet is formed at the outlet. The jet breaks up into microbubbles which are collected in a suitable liquid. In this work, co-axial electrohydrodynamic microbubbling was used to prepare microbubbles from a phospholipid suspension containing 2 wt-% Tween 80, a surfactant. Microbubbling was carried out under different electrical fields and air/liquid flowrates in order to prepare microbubbles with a low polydispersivity index. At the ambient temperature, the microbubbles collected in distilled water had a mean diameter of ∼5 μm with a polydispersivity index of ∼9% and were stable for >18 h. © 2009 Institute of Materials, Minerals and Mining. |
| spellingShingle | Farook, U Stride, E Edirisinghe, M Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title | Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title_full | Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title_fullStr | Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title_full_unstemmed | Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title_short | Controlling size and size distribution of electrohydrodynamically prepared microbubbles |
| title_sort | controlling size and size distribution of electrohydrodynamically prepared microbubbles |
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