Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game
In this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal co-administration of protein antigen with a strong MAIT cell ligand results in the the production of mucosal IgA and IgG antibody...
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| Format: | Journal article |
| Language: | English |
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Wiley
2023
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| _version_ | 1811139143571341312 |
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| author | Provine, NM |
| author_facet | Provine, NM |
| author_sort | Provine, NM |
| collection | OXFORD |
| description | In this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal co-administration of protein antigen with a strong MAIT cell ligand results in the the production of mucosal IgA and IgG antibody responses. This process is driven by MAIT cell-mediated maturation of migratory dendritic cells. |
| first_indexed | 2024-03-07T08:22:51Z |
| format | Journal article |
| id | oxford-uuid:31e9895d-af6f-433e-80ff-f4e676c936c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:01:24Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:31e9895d-af6f-433e-80ff-f4e676c936c52024-05-03T08:50:21ZTargeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old gameJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:31e9895d-af6f-433e-80ff-f4e676c936c5EnglishSymplectic ElementsWiley2023Provine, NMIn this article, I discuss recent work by Pankhurst et al. They found that MAIT cells can serve as a cellular adjuvant to boost immunity to a protein adjuvant. Intranasal co-administration of protein antigen with a strong MAIT cell ligand results in the the production of mucosal IgA and IgG antibody responses. This process is driven by MAIT cell-mediated maturation of migratory dendritic cells. |
| spellingShingle | Provine, NM Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title | Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title_full | Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title_fullStr | Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title_full_unstemmed | Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title_short | Targeting MAIT cells as a cellular adjuvant for humoral immunity: a new player in a very old game |
| title_sort | targeting mait cells as a cellular adjuvant for humoral immunity a new player in a very old game |
| work_keys_str_mv | AT provinenm targetingmaitcellsasacellularadjuvantforhumoralimmunityanewplayerinaveryoldgame |