The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies.
Although there are various ways in which the regulation of hypothalamic corticotropin-releasing factor (CRF) may be investigated, the most direct is by the study of CRF secretion from rat hypothalami incubated in vitro. Using this technique, we have found stimulation of secretion by noradrenaline, a...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1993
|
| _version_ | 1797061619060047872 |
|---|---|
| author | Grossman, A Costa, A Navarra, P Tsagarakis, S |
| author_facet | Grossman, A Costa, A Navarra, P Tsagarakis, S |
| author_sort | Grossman, A |
| collection | OXFORD |
| description | Although there are various ways in which the regulation of hypothalamic corticotropin-releasing factor (CRF) may be investigated, the most direct is by the study of CRF secretion from rat hypothalami incubated in vitro. Using this technique, we have found stimulation of secretion by noradrenaline, acetylcholine, serotonin, neuropeptide Y, and interleukins 1 and 6; inhibitory modulation was shown by GABA, substance P, atrial natriuretic peptide, opioid peptides and precursors of nitric oxide. Studies of these interactions demonstrated certain non-linear characteristics which may allow appropriate mathematical models to be devised; this may aid in our understanding of clinical disorders associated with CRF excess. |
| first_indexed | 2024-03-06T20:33:48Z |
| format | Journal article |
| id | oxford-uuid:31f25892-53fb-4a7f-8201-51a75a312988 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:33:48Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:31f25892-53fb-4a7f-8201-51a75a3129882022-03-26T13:10:59ZThe regulation of hypothalamic corticotropin-releasing factor release: in vitro studies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:31f25892-53fb-4a7f-8201-51a75a312988EnglishSymplectic Elements at Oxford1993Grossman, ACosta, ANavarra, PTsagarakis, SAlthough there are various ways in which the regulation of hypothalamic corticotropin-releasing factor (CRF) may be investigated, the most direct is by the study of CRF secretion from rat hypothalami incubated in vitro. Using this technique, we have found stimulation of secretion by noradrenaline, acetylcholine, serotonin, neuropeptide Y, and interleukins 1 and 6; inhibitory modulation was shown by GABA, substance P, atrial natriuretic peptide, opioid peptides and precursors of nitric oxide. Studies of these interactions demonstrated certain non-linear characteristics which may allow appropriate mathematical models to be devised; this may aid in our understanding of clinical disorders associated with CRF excess. |
| spellingShingle | Grossman, A Costa, A Navarra, P Tsagarakis, S The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title | The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title_full | The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title_fullStr | The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title_full_unstemmed | The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title_short | The regulation of hypothalamic corticotropin-releasing factor release: in vitro studies. |
| title_sort | regulation of hypothalamic corticotropin releasing factor release in vitro studies |
| work_keys_str_mv | AT grossmana theregulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT costaa theregulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT navarrap theregulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT tsagarakiss theregulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT grossmana regulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT costaa regulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT navarrap regulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies AT tsagarakiss regulationofhypothalamiccorticotropinreleasingfactorreleaseinvitrostudies |