Repeated electroconvulsive shock does not increase the susceptibility of rats to a cage convulsant (isopropylbicyclophosphate).

Repeated electroconvulsive shock does not increase the susceptibility of rats to a cage convulsant (isopropylbicyclophosphate).

Intravenous infusion of isopropylbicyclophosphate (IPTBO), a cage convulsant, produced a seizure which was qualitatively very similar to that seen after picrotoxin administration, but with a shorter latency. Pretreatment of rats with either a single electroconvulsive shock (ECS) or a single ECS dail...

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Bibliografiske detaljer
Main Authors: Cowen, P, Nutt, D, Green, A
Format: Journal article
Sprog:English
Udgivet: 1980
Beskrivelse
Summary:Intravenous infusion of isopropylbicyclophosphate (IPTBO), a cage convulsant, produced a seizure which was qualitatively very similar to that seen after picrotoxin administration, but with a shorter latency. Pretreatment of rats with either a single electroconvulsive shock (ECS) or a single ECS daily for 10 days did not alter the dose of IPTBO necessary to elicit a seizure 24 h after the final ECS. This data together with other previously published work argues against repeated ECS altering seizure susceptibility in rats.

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