The impact of off-pump coronary artery bypass surgery on postoperative renal function.
OBJECTIVES: A number of risk factors have been recognised for postoperative renal dysfunction following on-pump coronary artery bypass surgery (CABG). There are, however, few studies that have evaluated the potential reno-protective effects of off-pump CABG in the presence of other confounding risk...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797061636808245248 |
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| author | Abu-Omar, Y Taghavi, F Navaratnarajah, M Ali, A Shahir, A Yu, L Choong, C Taggart, D |
| author_facet | Abu-Omar, Y Taghavi, F Navaratnarajah, M Ali, A Shahir, A Yu, L Choong, C Taggart, D |
| author_sort | Abu-Omar, Y |
| collection | OXFORD |
| description | OBJECTIVES: A number of risk factors have been recognised for postoperative renal dysfunction following on-pump coronary artery bypass surgery (CABG). There are, however, few studies that have evaluated the potential reno-protective effects of off-pump CABG in the presence of other confounding risk factors. The aim of this study was to determine if off-pump CABG reduces the risk of renal injury. METHODS: Serum creatinine values (preoperatively and day 1, 2 and 4 postoperatively) and other clinical data were prospectively collected on 1580 consecutive patients who underwent first-time CABG from 2002 to 2005. Creatinine clearance was calculated using the Cockcroft and Gault equation. The effect of on-pump vs. off-pump CABG on renal function was analysed, adjusting for age, gender, diabetes mellitus, left ventricular (LV) function and preoperative creatinine clearance, using multiple regression analysis. RESULTS: One thousand one hundred and forty-five (73%) patients underwent on-pump CABG and 435 (27%) underwent off-pump CABG. The two groups were similar with respect to age, gender and diabetes. Two hundred and seventy-four (17%) patients were females and 274 (17%) patients had diabetes. Multivariate analysis demonstrated significantly lower creatinine clearance postoperatively in patients with diabetes (P<0.001) and advanced age (P<0.001). The on-pump group had significantly lower postoperative creatinine clearance in comparison to the off-pump group (P= 0.01). The effect remained consistent after adjusting for potential risk factors (age, diabetes, gender, LV function and preoperative creatinine clearance) in the multivariate analysis. CONCLUSION: Off-pump surgery is associated with a reduction in postoperative renal injury. |
| first_indexed | 2024-03-06T20:34:04Z |
| format | Journal article |
| id | oxford-uuid:320530ae-c300-4628-9115-134269488288 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:34:04Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:320530ae-c300-4628-9115-1342694882882022-03-26T13:11:31ZThe impact of off-pump coronary artery bypass surgery on postoperative renal function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:320530ae-c300-4628-9115-134269488288EnglishSymplectic Elements at Oxford2012Abu-Omar, YTaghavi, FNavaratnarajah, MAli, AShahir, AYu, LChoong, CTaggart, D OBJECTIVES: A number of risk factors have been recognised for postoperative renal dysfunction following on-pump coronary artery bypass surgery (CABG). There are, however, few studies that have evaluated the potential reno-protective effects of off-pump CABG in the presence of other confounding risk factors. The aim of this study was to determine if off-pump CABG reduces the risk of renal injury. METHODS: Serum creatinine values (preoperatively and day 1, 2 and 4 postoperatively) and other clinical data were prospectively collected on 1580 consecutive patients who underwent first-time CABG from 2002 to 2005. Creatinine clearance was calculated using the Cockcroft and Gault equation. The effect of on-pump vs. off-pump CABG on renal function was analysed, adjusting for age, gender, diabetes mellitus, left ventricular (LV) function and preoperative creatinine clearance, using multiple regression analysis. RESULTS: One thousand one hundred and forty-five (73%) patients underwent on-pump CABG and 435 (27%) underwent off-pump CABG. The two groups were similar with respect to age, gender and diabetes. Two hundred and seventy-four (17%) patients were females and 274 (17%) patients had diabetes. Multivariate analysis demonstrated significantly lower creatinine clearance postoperatively in patients with diabetes (P<0.001) and advanced age (P<0.001). The on-pump group had significantly lower postoperative creatinine clearance in comparison to the off-pump group (P= 0.01). The effect remained consistent after adjusting for potential risk factors (age, diabetes, gender, LV function and preoperative creatinine clearance) in the multivariate analysis. CONCLUSION: Off-pump surgery is associated with a reduction in postoperative renal injury. |
| spellingShingle | Abu-Omar, Y Taghavi, F Navaratnarajah, M Ali, A Shahir, A Yu, L Choong, C Taggart, D The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title | The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title_full | The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title_fullStr | The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title_full_unstemmed | The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title_short | The impact of off-pump coronary artery bypass surgery on postoperative renal function. |
| title_sort | impact of off pump coronary artery bypass surgery on postoperative renal function |
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