Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains lar...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Ku, C, von Bernuth, H, Picard, C, Zhang, S, Chang, H, Yang, K, Chrabieh, M, Issekutz, A, Cunningham, C, Gallin, J, Holland, S, Roifman, C, Ehl, S, Smart, J, Tang, M, Barrat, F, Levy, O, McDonald, D, Day-Good, N, Miller, R, Takada, H, Hara, T, Al-Hajjar, S, Al-Ghonaium, A, Speert, D
Format:	Journal article
Sprache:	English
Veröffentlicht:	2007

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

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