Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains lar...

Description complète

Détails bibliographiques
Auteurs principaux: Ku, C, von Bernuth, H, Picard, C, Zhang, S, Chang, H, Yang, K, Chrabieh, M, Issekutz, A, Cunningham, C, Gallin, J, Holland, S, Roifman, C, Ehl, S, Smart, J, Tang, M, Barrat, F, Levy, O, McDonald, D, Day-Good, N, Miller, R, Takada, H, Hara, T, Al-Hajjar, S, Al-Ghonaium, A, Speert, D
Format: Journal article
Langue:English
Publié: 2007

Documents similaires