Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care

As currently designed and conducted, randomized controlled trials rarely address the complexity of patient characteristics that need to be taken into account when making clinical decisions in primary care. We introduce the concept of a response adaptive, platform trial design, as this approach may...

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Main Authors: Butler, C, Connor, J, Lewis, R, Broglio, K, Saville, B, Cook, J, van der Velden, A, Verheij, T
Format: Journal article
Language:English
Published: Royal College of General Practitioners 2018
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author Butler, C
Connor, J
Lewis, R
Broglio, K
Saville, B
Cook, J
van der Velden, A
Verheij, T
author_facet Butler, C
Connor, J
Lewis, R
Broglio, K
Saville, B
Cook, J
van der Velden, A
Verheij, T
author_sort Butler, C
collection OXFORD
description As currently designed and conducted, randomized controlled trials rarely address the complexity of patient characteristics that need to be taken into account when making clinical decisions in primary care. We introduce the concept of a response adaptive, platform trial design, as this approach may be better suited to answering patient-centred, primary care research questions.
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spelling oxford-uuid:321698de-f92a-4972-b323-ed5c87db606a2022-03-26T13:11:52ZAnswering patient-centred questions efficiently: Response-adaptive platform trials in primary careJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:321698de-f92a-4972-b323-ed5c87db606aEnglishSymplectic Elements at OxfordRoyal College of General Practitioners2018Butler, CConnor, JLewis, RBroglio, KSaville, BCook, Jvan der Velden, AVerheij, TAs currently designed and conducted, randomized controlled trials rarely address the complexity of patient characteristics that need to be taken into account when making clinical decisions in primary care. We introduce the concept of a response adaptive, platform trial design, as this approach may be better suited to answering patient-centred, primary care research questions.
spellingShingle Butler, C
Connor, J
Lewis, R
Broglio, K
Saville, B
Cook, J
van der Velden, A
Verheij, T
Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title_full Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title_fullStr Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title_full_unstemmed Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title_short Answering patient-centred questions efficiently: Response-adaptive platform trials in primary care
title_sort answering patient centred questions efficiently response adaptive platform trials in primary care
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AT brogliok answeringpatientcentredquestionsefficientlyresponseadaptiveplatformtrialsinprimarycare
AT savilleb answeringpatientcentredquestionsefficientlyresponseadaptiveplatformtrialsinprimarycare
AT cookj answeringpatientcentredquestionsefficientlyresponseadaptiveplatformtrialsinprimarycare
AT vanderveldena answeringpatientcentredquestionsefficientlyresponseadaptiveplatformtrialsinprimarycare
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