Mouse models of human chromosomal translocations and approaches to cancer therapy.

Mouse models of human chromosomal translocations and approaches to cancer therapy.

Cancer arises because of genetic changes in somatic cells, eventually giving rise to overt malignancy. Principle among genetic changes found in tumor cells are chromosomal translocations which give rise to fusion genes or enforced oncogene expression. These mutations are tumor-specific and result in...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Rabbitts, T, Appert, A, Chung, G, Collins, E, Drynan, L, Forster, A, Lobato, M, McCormack, M, Pannell, R, Spandidos, A, Stocks, MR, Tanaka, T, Tse, E
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2001

Παρόμοια τεκμήρια

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
ανά: Forster, A, κ.ά.
Έκδοση: (2003)

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
ανά: McCormack, M, κ.ά.
Έκδοση: (2003)

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
ανά: Lobato, M, κ.ά.
Έκδοση: (2008)

Chromosomal translocation engineering to recapitulate primary events of human cancer.
ανά: Forster, A, κ.ά.
Έκδοση: (2005)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
ανά: Collins, E, κ.ά.
Έκδοση: (2002)

Chromosomal translocation products engender new intracellular therapeutic technologies.
ανά: Rabbitts, T, κ.ά.
Έκδοση: (2003)

Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.
ανά: Cano, F, κ.ά.
Έκδοση: (2008)

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.
ανά: Collins, E, κ.ά.
Έκδοση: (2000)

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.
ανά: Drynan, L, κ.ά.
Έκδοση: (2005)

An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions.
ανά: Nam, C, κ.ά.
Έκδοση: (2008)

Chromosomal translocation master genes, mouse models and experimental therapeutics.
ανά: Rabbitts, T
Έκδοση: (2001)

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
ανά: Collins, E, κ.ά.
Έκδοση: (2002)

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
ανά: Codrington, R, κ.ά.
Έκδοση: (2005)

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
ανά: Tse, E, κ.ά.
Έκδοση: (2002)

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.
ανά: Appert, A, κ.ά.
Έκδοση: (2009)

LMO2 at 25 years: a paradigm of chromosomal translocation proteins
ανά: Jennifer Chambers, κ.ά.
Έκδοση: (2015-01-01)

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.
ανά: Nam, C, κ.ά.
Έκδοση: (2006)

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.
ανά: Rosalind Codrington, κ.ά.
Έκδοση: (2005-08-01)

Sub-proteome differential display: single gel comparison by 2D electrophoresis and mass spectrometry.
ανά: Spandidos, A, κ.ά.
Έκδοση: (2002)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription.
ανά: Ali, H, κ.ά.
Έκδοση: (2013)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription
ανά: Ali, H, κ.ά.
Έκδοση: (2013)

De novo production of diverse intracellular antibody libraries.
ανά: Tanaka, T, κ.ά.
Έκδοση: (2003)

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.
ανά: Metzler, M, κ.ά.
Έκδοση: (2006)

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
ανά: McCormack, M, κ.ά.
Έκδοση: (2004)

Masked antisense: a molecular configuration for discriminating similar RNA targets.
ανά: Stocks, MR, κ.ά.
Έκδοση: (2000)

The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
ανά: Chung, G, κ.ά.
Έκδοση: (2003)

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias.
ανά: Cano, F, κ.ά.
Έκδοση: (2008)

The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target.
ανά: Yamada, Y, κ.ά.
Έκδοση: (2002)

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.
ανά: Yamada, Y, κ.ά.
Έκδοση: (2000)

T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
ανά: Drynan, L, κ.ά.
Έκδοση: (2001)

c-Myc—Dependent Formation of Robertsonian Translocation Chromosomes in Mouse Cells
ανά: Amanda Guffei, κ.ά.
Έκδοση: (2007-07-01)

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
ανά: Dobson, C, κ.ά.
Έκδοση: (2000)

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.
ανά: Pezzella, F, κ.ά.
Έκδοση: (1990)

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.
ανά: Tanaka, T, κ.ά.
Έκδοση: (2003)

Erratum: Interrogation of genomes by molecular copy-number counting (MCC) (Nature Methods (2006) vol. 3 (447-453))
ανά: Daser, A, κ.ά.
Έκδοση: (2006)

Interrogation of genomes by molecular copy-number counting (MCC).
ανά: Daser, A, κ.ά.
Έκδοση: (2006)

Relations between ultrastructure of mitotic spindle and chromosome translocation
ανά: Jadwiga A. Tarkowska
Έκδοση: (2014-01-01)

Timing language disorders with a chromosomal translocation in 7q31
ανά: Garcia-Bellido, E, κ.ά.
Έκδοση: (2012)

The T cell oncogene Tal2 is necessary for normal development of the mouse brain.
ανά: Bucher, K, κ.ά.
Έκδοση: (2000)

Time interval integration with a chromosomal translocation affecting 7q31
ανά: Garcia-Bellido, E, κ.ά.
Έκδοση: (2012)