Mouse models of human chromosomal translocations and approaches to cancer therapy.

Mouse models of human chromosomal translocations and approaches to cancer therapy.

Cancer arises because of genetic changes in somatic cells, eventually giving rise to overt malignancy. Principle among genetic changes found in tumor cells are chromosomal translocations which give rise to fusion genes or enforced oncogene expression. These mutations are tumor-specific and result in...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Rabbitts, T, Appert, A, Chung, G, Collins, E, Drynan, L, Forster, A, Lobato, M, McCormack, M, Pannell, R, Spandidos, A, Stocks, MR, Tanaka, T, Tse, E
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2001

Míreanna comhchosúla

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
de réir: Forster, A, et al.
Foilsithe / Cruthaithe: (2003)

The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
de réir: McCormack, M, et al.
Foilsithe / Cruthaithe: (2003)

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
de réir: Lobato, M, et al.
Foilsithe / Cruthaithe: (2008)

Chromosomal translocation engineering to recapitulate primary events of human cancer.
de réir: Forster, A, et al.
Foilsithe / Cruthaithe: (2005)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
de réir: Collins, E, et al.
Foilsithe / Cruthaithe: (2002)

Chromosomal translocation products engender new intracellular therapeutic technologies.
de réir: Rabbitts, T, et al.
Foilsithe / Cruthaithe: (2003)

Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.
de réir: Cano, F, et al.
Foilsithe / Cruthaithe: (2008)

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.
de réir: Collins, E, et al.
Foilsithe / Cruthaithe: (2000)

Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis.
de réir: Drynan, L, et al.
Foilsithe / Cruthaithe: (2005)

An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions.
de réir: Nam, C, et al.
Foilsithe / Cruthaithe: (2008)

Chromosomal translocation master genes, mouse models and experimental therapeutics.
de réir: Rabbitts, T
Foilsithe / Cruthaithe: (2001)

The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
de réir: Collins, E, et al.
Foilsithe / Cruthaithe: (2002)

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells
de réir: Codrington, R, et al.
Foilsithe / Cruthaithe: (2005)

Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
de réir: Tse, E, et al.
Foilsithe / Cruthaithe: (2002)

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.
de réir: Appert, A, et al.
Foilsithe / Cruthaithe: (2009)

LMO2 at 25 years: a paradigm of chromosomal translocation proteins
de réir: Jennifer Chambers, et al.
Foilsithe / Cruthaithe: (2015-01-01)

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion.
de réir: Nam, C, et al.
Foilsithe / Cruthaithe: (2006)

The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.
de réir: Rosalind Codrington, et al.
Foilsithe / Cruthaithe: (2005-08-01)

Sub-proteome differential display: single gel comparison by 2D electrophoresis and mass spectrometry.
de réir: Spandidos, A, et al.
Foilsithe / Cruthaithe: (2002)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription.
de réir: Ali, H, et al.
Foilsithe / Cruthaithe: (2013)

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription
de réir: Ali, H, et al.
Foilsithe / Cruthaithe: (2013)

De novo production of diverse intracellular antibody libraries.
de réir: Tanaka, T, et al.
Foilsithe / Cruthaithe: (2003)

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.
de réir: Metzler, M, et al.
Foilsithe / Cruthaithe: (2006)

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency.
de réir: McCormack, M, et al.
Foilsithe / Cruthaithe: (2004)

Masked antisense: a molecular configuration for discriminating similar RNA targets.
de réir: Stocks, MR, et al.
Foilsithe / Cruthaithe: (2000)

The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
de réir: Chung, G, et al.
Foilsithe / Cruthaithe: (2003)

Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias.
de réir: Cano, F, et al.
Foilsithe / Cruthaithe: (2008)

The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target.
de réir: Yamada, Y, et al.
Foilsithe / Cruthaithe: (2002)

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.
de réir: Yamada, Y, et al.
Foilsithe / Cruthaithe: (2000)

T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
de réir: Drynan, L, et al.
Foilsithe / Cruthaithe: (2001)

c-Myc—Dependent Formation of Robertsonian Translocation Chromosomes in Mouse Cells
de réir: Amanda Guffei, et al.
Foilsithe / Cruthaithe: (2007-07-01)

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.
de réir: Dobson, C, et al.
Foilsithe / Cruthaithe: (2000)

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.
de réir: Pezzella, F, et al.
Foilsithe / Cruthaithe: (1990)

Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.
de réir: Tanaka, T, et al.
Foilsithe / Cruthaithe: (2003)

Erratum: Interrogation of genomes by molecular copy-number counting (MCC) (Nature Methods (2006) vol. 3 (447-453))
de réir: Daser, A, et al.
Foilsithe / Cruthaithe: (2006)

Interrogation of genomes by molecular copy-number counting (MCC).
de réir: Daser, A, et al.
Foilsithe / Cruthaithe: (2006)

Relations between ultrastructure of mitotic spindle and chromosome translocation
de réir: Jadwiga A. Tarkowska
Foilsithe / Cruthaithe: (2014-01-01)

Timing language disorders with a chromosomal translocation in 7q31
de réir: Garcia-Bellido, E, et al.
Foilsithe / Cruthaithe: (2012)

The T cell oncogene Tal2 is necessary for normal development of the mouse brain.
de réir: Bucher, K, et al.
Foilsithe / Cruthaithe: (2000)

Time interval integration with a chromosomal translocation affecting 7q31
de réir: Garcia-Bellido, E, et al.
Foilsithe / Cruthaithe: (2012)