Mouse models of human chromosomal translocations and approaches to cancer therapy.
Cancer arises because of genetic changes in somatic cells, eventually giving rise to overt malignancy. Principle among genetic changes found in tumor cells are chromosomal translocations which give rise to fusion genes or enforced oncogene expression. These mutations are tumor-specific and result in...
Հիմնական հեղինակներ: | Rabbitts, T, Appert, A, Chung, G, Collins, E, Drynan, L, Forster, A, Lobato, M, McCormack, M, Pannell, R, Spandidos, A, Stocks, MR, Tanaka, T, Tse, E |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2001
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Նմանատիպ նյութեր
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Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer.
: Forster, A, և այլն
Հրապարակվել է: (2003) -
The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
: McCormack, M, և այլն
Հրապարակվել է: (2003) -
Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.
: Lobato, M, և այլն
Հրապարակվել է: (2008) -
Chromosomal translocation engineering to recapitulate primary events of human cancer.
: Forster, A, և այլն
Հրապարակվել է: (2005) -
Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
: Collins, E, և այլն
Հրապարակվել է: (2002)