Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases
<p><strong>Background</strong> Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular...
| Váldodahkkit: | , , , , , , , , , , |
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| Materiálatiipa: | Journal article |
| Giella: | English |
| Almmustuhtton: |
Elsevier
2018
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| _version_ | 1826266139044347904 |
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| author | Ntusi, N Francis, J Sever, E Liu, A Piechnik, S Ferreira, V Matthews, P Robson, M Wordsworth, P Neubauer, S Karamitsos, T |
| author_facet | Ntusi, N Francis, J Sever, E Liu, A Piechnik, S Ferreira, V Matthews, P Robson, M Wordsworth, P Neubauer, S Karamitsos, T |
| author_sort | Ntusi, N |
| collection | OXFORD |
| description | <p><strong>Background</strong> Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood.</p> <p><strong>Objectives</strong> We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR).</p> <p><strong>Methods</strong> 20 RA patients, 7 AS patients, 5 PsA patients without previously known CVD scheduled to commence anti-TNF therapy and 8 RA patients on standard disease modifying antirheumatic drugs underwent CMR at 1.5 T, including cine, tagging, pulse wave velocity (PWV), T2-weighted, native and postcontrast T1 mapping, ECV quantification, rest and stress perfusion and late gadolinium enhancement (LGE) imaging.</p> <p><strong>Results</strong> Following anti-TNF therapy, there was significant reversal of baseline subclinical cardiovascular dysfunction, as evidenced by improvement in peak systolic circumferential strain (p ≺ 0.001), peak diastolic circumferential strain rate (p ≺0.001), and total aortic PWV, (p≺ 0.001). This was accompanied by a reduction in myocardial inflammation, as assessed by T2-weighted imaging (p = 0.005), native T1 mapping (p = 0.009) and ECV quantification (p = 0.001), as well as in serum inflammatory markers like CRP (p ≺ 0.001) and ESR (p≺ 0.001), and clinical measures of disease activity (DAS28-CRP, p = 0.001; BASDAI, p ≺ 0.001). A trend towards improvement in myocardial perfusion was observed (p = 0.07). Focal myocardial fibrosis, as detected by LGE CMR was not altered by anti-TNF therapy (p = 0.92).</p> <p><strong>Conclusions</strong> Anti-TNF therapy reduces subclinical myocardial inflammation and improves cardiovascular function in RA, AS and PsA. CMR may be used to track disease progression and response to therapy. Future CMR-based studies to demonstrate effect of anti-TNF therapy modulation of vascular structure and function on hard clinical events and outcomes would be useful.</p> |
| first_indexed | 2024-03-06T20:34:24Z |
| format | Journal article |
| id | oxford-uuid:322289ba-7d46-4d77-8a37-7d5320a0850d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:34:24Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:322289ba-7d46-4d77-8a37-7d5320a0850d2022-03-26T13:12:08ZAnti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseasesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:322289ba-7d46-4d77-8a37-7d5320a0850dEnglishSymplectic Elements at OxfordElsevier2018Ntusi, NFrancis, JSever, ELiu, APiechnik, SFerreira, VMatthews, PRobson, MWordsworth, PNeubauer, SKaramitsos, T<p><strong>Background</strong> Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood.</p> <p><strong>Objectives</strong> We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR).</p> <p><strong>Methods</strong> 20 RA patients, 7 AS patients, 5 PsA patients without previously known CVD scheduled to commence anti-TNF therapy and 8 RA patients on standard disease modifying antirheumatic drugs underwent CMR at 1.5 T, including cine, tagging, pulse wave velocity (PWV), T2-weighted, native and postcontrast T1 mapping, ECV quantification, rest and stress perfusion and late gadolinium enhancement (LGE) imaging.</p> <p><strong>Results</strong> Following anti-TNF therapy, there was significant reversal of baseline subclinical cardiovascular dysfunction, as evidenced by improvement in peak systolic circumferential strain (p ≺ 0.001), peak diastolic circumferential strain rate (p ≺0.001), and total aortic PWV, (p≺ 0.001). This was accompanied by a reduction in myocardial inflammation, as assessed by T2-weighted imaging (p = 0.005), native T1 mapping (p = 0.009) and ECV quantification (p = 0.001), as well as in serum inflammatory markers like CRP (p ≺ 0.001) and ESR (p≺ 0.001), and clinical measures of disease activity (DAS28-CRP, p = 0.001; BASDAI, p ≺ 0.001). A trend towards improvement in myocardial perfusion was observed (p = 0.07). Focal myocardial fibrosis, as detected by LGE CMR was not altered by anti-TNF therapy (p = 0.92).</p> <p><strong>Conclusions</strong> Anti-TNF therapy reduces subclinical myocardial inflammation and improves cardiovascular function in RA, AS and PsA. CMR may be used to track disease progression and response to therapy. Future CMR-based studies to demonstrate effect of anti-TNF therapy modulation of vascular structure and function on hard clinical events and outcomes would be useful.</p> |
| spellingShingle | Ntusi, N Francis, J Sever, E Liu, A Piechnik, S Ferreira, V Matthews, P Robson, M Wordsworth, P Neubauer, S Karamitsos, T Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title | Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title_full | Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title_fullStr | Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title_full_unstemmed | Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title_short | Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
| title_sort | anti tnf modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases |
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