Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis.
A 51-year-old man presented with intermittent fever, mild cough and loss of appetite of 1-month duration. His sputum smear was positive for acid-fast bacilli and his chest radiograph revealed apical infiltrations. The patient was treated with antitubercular therapy (ATT), recovered and was well for...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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BMJ Publishing Group
2016
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| _version_ | 1797061670442369024 |
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| author | Paudyal, B Paudel, K Shakya, M Basnyat, B |
| author_facet | Paudyal, B Paudel, K Shakya, M Basnyat, B |
| author_sort | Paudyal, B |
| collection | OXFORD |
| description | A 51-year-old man presented with intermittent fever, mild cough and loss of appetite of 1-month duration. His sputum smear was positive for acid-fast bacilli and his chest radiograph revealed apical infiltrations. The patient was treated with antitubercular therapy (ATT), recovered and was well for 1 month, after which he suddenly developed focal seizures. MRI of the brain with gadolinium enhancement showed high intensity nodular foci in the frontal, parietal and occipital regions. The patient was diagnosed as a case of paradoxical reaction to ATT, and was successfully managed with continued ATT and adjunctive steroid therapy. |
| first_indexed | 2024-03-06T20:34:33Z |
| format | Journal article |
| id | oxford-uuid:322e0b14-97fb-441d-abae-2934f542dc52 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:34:33Z |
| publishDate | 2016 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:322e0b14-97fb-441d-abae-2934f542dc522022-03-26T13:12:29ZParadoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:322e0b14-97fb-441d-abae-2934f542dc52EnglishSymplectic Elements at OxfordBMJ Publishing Group2016Paudyal, BPaudel, KShakya, MBasnyat, BA 51-year-old man presented with intermittent fever, mild cough and loss of appetite of 1-month duration. His sputum smear was positive for acid-fast bacilli and his chest radiograph revealed apical infiltrations. The patient was treated with antitubercular therapy (ATT), recovered and was well for 1 month, after which he suddenly developed focal seizures. MRI of the brain with gadolinium enhancement showed high intensity nodular foci in the frontal, parietal and occipital regions. The patient was diagnosed as a case of paradoxical reaction to ATT, and was successfully managed with continued ATT and adjunctive steroid therapy. |
| spellingShingle | Paudyal, B Paudel, K Shakya, M Basnyat, B Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title | Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title_full | Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title_fullStr | Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title_full_unstemmed | Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title_short | Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis. |
| title_sort | paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis |
| work_keys_str_mv | AT paudyalb paradoxicalreactiontoantituberculartreatmentinacaseofpulmonarytuberculosis AT paudelk paradoxicalreactiontoantituberculartreatmentinacaseofpulmonarytuberculosis AT shakyam paradoxicalreactiontoantituberculartreatmentinacaseofpulmonarytuberculosis AT basnyatb paradoxicalreactiontoantituberculartreatmentinacaseofpulmonarytuberculosis |