QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.
OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from c...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2007
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| _version_ | 1826266152424177664 |
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| author | Sokka, T Kautiainen, H Toloza, S Mäkinen, H Verstappen, S Lund Hetland, M Naranjo, A Baecklund, E Herborn, G Rau, R Cazzato, M Gossec, L Skakic, V Gogus, F Sierakowski, S Bresnihan, B Taylor, P McClinton, C Pincus, T |
| author_facet | Sokka, T Kautiainen, H Toloza, S Mäkinen, H Verstappen, S Lund Hetland, M Naranjo, A Baecklund, E Herborn, G Rau, R Cazzato, M Gossec, L Skakic, V Gogus, F Sierakowski, S Bresnihan, B Taylor, P McClinton, C Pincus, T |
| author_sort | Sokka, T |
| collection | OXFORD |
| description | OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 <or=3.2 countries,="" countries;="" eight="" five="" found="" in="" majority="" of="" other="" patients="" seven="" sites="" the="" was="">50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.</or=3.2> |
| first_indexed | 2024-03-06T20:34:36Z |
| format | Journal article |
| id | oxford-uuid:322ffea7-b67c-4cf7-88e4-7314dd7959ed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:34:36Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:322ffea7-b67c-4cf7-88e4-7314dd7959ed2022-03-26T13:12:34ZQUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:322ffea7-b67c-4cf7-88e4-7314dd7959edEnglishSymplectic Elements at Oxford2007Sokka, TKautiainen, HToloza, SMäkinen, HVerstappen, SLund Hetland, MNaranjo, ABaecklund, EHerborn, GRau, RCazzato, MGossec, LSkakic, VGogus, FSierakowski, SBresnihan, BTaylor, PMcClinton, CPincus, T OBJECTIVE: To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA. METHODS: The review included current disease activity using data from clinical assessment and a patient self-report questionnaire, which was translated into each language. Data on demographic, disease and treatment-related variables were collected and analysed using descriptive statistics. Variation in disease activity on DAS28 (disease activity score on 28-joint count) within and between countries was graphically analysed. A median regression model was applied to analyse differences in disease activity between countries. RESULTS: Between January 2005 and October 2006, the QUEST-RA (Quantitative Patient Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis) project included 4363 patients from 48 sites in 15 countries; 78% were female, >90% Caucasian, mean age was 57 years and mean disease duration was 11.5 years. More than 80% of patients had been treated with methotrexate in all but three countries. Overall, patients had an active disease with a median DAS28 of 4.0, with a significant variation between countries (p<0.001). Among 42 sites with >50 patients included, low disease activity of DAS28 <or=3.2 countries,="" countries;="" eight="" five="" found="" in="" majority="" of="" other="" patients="" seven="" sites="" the="" was="">50% of patients had high disease activity of DAS28 >5.1. CONCLUSIONS: This international multicentre cross-sectional database provides an overview of clinical status and treatments of patients with RA in standard clinical care in 2005-6 including countries that are infrequently involved in clinical research projects.</or=3.2> |
| spellingShingle | Sokka, T Kautiainen, H Toloza, S Mäkinen, H Verstappen, S Lund Hetland, M Naranjo, A Baecklund, E Herborn, G Rau, R Cazzato, M Gossec, L Skakic, V Gogus, F Sierakowski, S Bresnihan, B Taylor, P McClinton, C Pincus, T QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title | QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title_full | QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title_fullStr | QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title_full_unstemmed | QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title_short | QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries. |
| title_sort | quest ra quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries |
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