Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Protein kinase C-theta mediates negative feedback on regulatory T cell function.

T cell receptor (TCR)-dependent regulatory T cell (Treg) activity controls effector T cell (Teff) function and is inhibited by the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Protein kinase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff acti...

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Bibliographic Details
Main Authors:	Zanin-Zhorov, A, Ding, Y, Kumari, S, Attur, M, Hippen, K, Brown, M, Blazar, B, Abramson, S, Lafaille, J, Dustin, M
Format:	Journal article
Language:	English
Published:	2010

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