CD4(+) T cell subsets during virus infection. Protective capacity depends on effector cytokine secretion and on migratory capability.

To analyze the antiviral protective capacities of CD4(+) T helper (Th) cell subsets, we used transgenic T cells expressing an I-A(b)-restricted T cell receptor specific for an epitope of vesicular stomatitis virus glycoprotein (VSV-G). After polarization into Th1 or Th2 effectors and adoptive transf...

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Hlavní autoři: Maloy, K, Burkhart, C, Junt, T, Odermatt, B, Oxenius, A, Piali, L, Zinkernagel, R, Hengartner, H
Médium: Journal article
Jazyk:English
Vydáno: 2000