Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons

Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system with complex determinants, including genetic and non-genetic factors. A key pathological signature of ALS is the cytoplasmic mislocalization and aggregation of TDP-43 in affected motor neurons, which is found in 9...

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Bibliographic Details
Main Authors: Dafinca, R, Tosat-Bitrian, C, Carroll, E, Vahsen, BF, Gilbert-Jaramillo, J, Scaber, J, Feneberg, E, Johnson, E, Talbot, K
Format: Journal article
Language:English
Published: Oxford University Press 2024

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