Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review
<p><strong>Introduction:</strong><br /> Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2020
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| _version_ | 1826266207605489664 |
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| author | Camfferman, FA de Goederen, R Govaert, P Dudink, J van Bel, F Pellicer, A Cools, F Alarcon Allen, A Roehr, C |
| author2 | eurUS.brain group |
| author_facet | eurUS.brain group Camfferman, FA de Goederen, R Govaert, P Dudink, J van Bel, F Pellicer, A Cools, F Alarcon Allen, A Roehr, C |
| author_sort | Camfferman, FA |
| collection | OXFORD |
| description | <p><strong>Introduction:</strong><br />
Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.</p><br />
<p><strong>Methods:</strong><br />
A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.</p><br />
<p><strong>Results:</strong><br />
In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.</p><br />
<p><strong>Discussion:</strong><br />
There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.</p> |
| first_indexed | 2024-03-06T20:35:24Z |
| format | Journal article |
| id | oxford-uuid:32743491-4e95-41f7-aabb-23ddfb155177 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:35:24Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:32743491-4e95-41f7-aabb-23ddfb1551772022-03-26T13:14:17ZDiagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:32743491-4e95-41f7-aabb-23ddfb155177EnglishSymplectic ElementsSpringer Nature2020Camfferman, FAde Goederen, RGovaert, PDudink, Jvan Bel, FPellicer, ACools, FAlarcon Allen, ARoehr, CeurUS.brain group<p><strong>Introduction:</strong><br /> Very and extremely preterm infants frequently have brain injury-related long-term neurodevelopmental problems. Altered perfusion, for example, seen in the context of a hemodynamically significant patent ductus arteriosus (PDA), has been linked to injury of the immature brain. However, a direct relation with outcome has not been reviewed systematically.</p><br /> <p><strong>Methods:</strong><br /> A systematic review was conducted to provide an overview of the value of different cerebral arterial blood flow parameters assessed by Doppler ultrasound, in relation to brain injury, to predict long-term neurodevelopmental outcome in preterm infants.</p><br /> <p><strong>Results:</strong><br /> In total, 23 studies were included. Because of heterogeneity of studies, a meta-analysis of results was not possible. All included studies on resistance index (RI) showed significantly higher values in subjects with a hemodynamically significant PDA. However, absolute differences in RI values were small. Studies using Doppler parameters to predict brain injury and long-term neurodevelopmental outcome were inconsistent.</p><br /> <p><strong>Discussion:</strong><br /> There is no clear evidence to support the routine determination of RI or other Doppler parameters in the cerebral arteries to predict brain injury and long-term neurodevelopmental outcome in the preterm infant. However, there is evidence that elevated RI can point to the presence of a hemodynamically significant PDA.</p> |
| spellingShingle | Camfferman, FA de Goederen, R Govaert, P Dudink, J van Bel, F Pellicer, A Cools, F Alarcon Allen, A Roehr, C Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title | Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title_full | Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title_fullStr | Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title_full_unstemmed | Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title_short | Diagnostic and predictive value of Doppler ultrasound for evaluation of the brain circulation in preterm infants: A systematic review |
| title_sort | diagnostic and predictive value of doppler ultrasound for evaluation of the brain circulation in preterm infants a systematic review |
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