Combining virotherapy and angiotherapy for the treatment of breast cancer.

A breast cancer-selective oncolytic adenovirus was engineered to express antagonists of vascular endothelial growth factor (VEGF) and Notch signaling to combine direct anticancer activity with disruption of tumor-associated angiogenesis. Replication of the parental virus, AdEHE2F, is stimulated by e...

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Bibliographic Details
Main Authors: Bazan-Peregrino, M, Sainson, R, Carlisle, R, Thoma, C, Waters, R, Arvanitis, C, Harris, A, Hernandez-Alcoceba, R, Seymour, L
Format: Journal article
Language:English
Published: 2013