A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling.

A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling.

In lymphocytes, integration of Ca2+ and other signalling pathways results in productive activation, while unopposed Ca2+ signalling leads to decreased responsiveness to subsequent stimulation (anergy). The Ca(2+)-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte...

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Main Authors: Heissmeyer, V, Macián, F, Varma, R, Im, S, García-Cozar, F, Horton, H, Byrne, M, Feske, S, Venuprasad, K, Gu, H, Liu, Y, Dustin, M, Rao, A
Format: Journal article
Language:English
Published: 2005

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