Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.
Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-contain...
| المؤلفون الرئيسيون: | , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2007
|
| الملخص: | Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing. |
|---|