Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.
Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-contain...
Main Authors: | , , , |
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Format: | Journal article |
Language: | English |
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2007
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_version_ | 1797061774619443200 |
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author | Liang, G Klose, R Gardner, K Zhang, Y |
author_facet | Liang, G Klose, R Gardner, K Zhang, Y |
author_sort | Liang, G |
collection | OXFORD |
description | Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing. |
first_indexed | 2024-03-06T20:36:05Z |
format | Journal article |
id | oxford-uuid:32ad065c-a3cd-43e8-b75d-a46d0e5c8d36 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T20:36:05Z |
publishDate | 2007 |
record_format | dspace |
spelling | oxford-uuid:32ad065c-a3cd-43e8-b75d-a46d0e5c8d362022-03-26T13:15:34ZYeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:32ad065c-a3cd-43e8-b75d-a46d0e5c8d36EnglishSymplectic Elements at Oxford2007Liang, GKlose, RGardner, KZhang, YHistone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing. |
spellingShingle | Liang, G Klose, R Gardner, K Zhang, Y Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title | Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title_full | Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title_fullStr | Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title_full_unstemmed | Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title_short | Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. |
title_sort | yeast jhd2p is a histone h3 lys4 trimethyl demethylase |
work_keys_str_mv | AT liangg yeastjhd2pisahistoneh3lys4trimethyldemethylase AT kloser yeastjhd2pisahistoneh3lys4trimethyldemethylase AT gardnerk yeastjhd2pisahistoneh3lys4trimethyldemethylase AT zhangy yeastjhd2pisahistoneh3lys4trimethyldemethylase |