Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs.

The anthracyclines, such as doxorubicin (DXR), are potent anti-cancer drugs but they are limited by their clinical toxicity. The mechanisms involved remain poorly understood partly because of the difficulty in determining sub-cellular drug localisation. Using a novel method utilising the fluorescent...

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Bibliografiska uppgifter
Huvudupphovsmän: Ashley, N, Poulton, J
Materialtyp: Journal article
Språk:English
Publicerad: 2009