A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed tha...
| मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Cell Press
2015
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| _version_ | 1826266308148199424 |
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| author | Douglas, A Baldeviano, G Lucas, C Lugo-Roman, L Crosnier, C Bartholdson, S Diouf, A Miura, K Lambert, L Ventocilla, J Leiva, K Milne, K Illingworth, J Spencer, A Hjerrild, K Alanine, D Turner, A Moorhead, J Edgel, K Wu, Y Long, C Wright, G Lescano, A Draper, S |
| author_facet | Douglas, A Baldeviano, G Lucas, C Lugo-Roman, L Crosnier, C Bartholdson, S Diouf, A Miura, K Lambert, L Ventocilla, J Leiva, K Milne, K Illingworth, J Spencer, A Hjerrild, K Alanine, D Turner, A Moorhead, J Edgel, K Wu, Y Long, C Wright, G Lescano, A Draper, S |
| author_sort | Douglas, A |
| collection | OXFORD |
| description | Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans. |
| first_indexed | 2024-03-06T20:36:55Z |
| format | Journal article |
| id | oxford-uuid:32f2ffc6-887f-40ac-a07d-2b08a4de7de4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:36:55Z |
| publishDate | 2015 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:32f2ffc6-887f-40ac-a07d-2b08a4de7de42022-03-26T13:17:16ZA PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:32f2ffc6-887f-40ac-a07d-2b08a4de7de4EnglishSymplectic Elements at OxfordCell Press2015Douglas, ABaldeviano, GLucas, CLugo-Roman, LCrosnier, CBartholdson, SDiouf, AMiura, KLambert, LVentocilla, JLeiva, KMilne, KIllingworth, JSpencer, AHjerrild, KAlanine, DTurner, AMoorhead, JEdgel, KWu, YLong, CWright, GLescano, ADraper, SAntigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans. |
| spellingShingle | Douglas, A Baldeviano, G Lucas, C Lugo-Roman, L Crosnier, C Bartholdson, S Diouf, A Miura, K Lambert, L Ventocilla, J Leiva, K Milne, K Illingworth, J Spencer, A Hjerrild, K Alanine, D Turner, A Moorhead, J Edgel, K Wu, Y Long, C Wright, G Lescano, A Draper, S A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title | A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title_full | A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title_fullStr | A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title_full_unstemmed | A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title_short | A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys. |
| title_sort | pfrh5 based vaccine is efficacious against heterologous strain blood stage plasmodium falciparum infection in aotus monkeys |
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