A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed tha...
Glavni autori: | Douglas, A, Baldeviano, G, Lucas, C, Lugo-Roman, L, Crosnier, C, Bartholdson, S, Diouf, A, Miura, K, Lambert, L, Ventocilla, J, Leiva, K, Milne, K, Illingworth, J, Spencer, A, Hjerrild, K, Alanine, D, Turner, A, Moorhead, J, Edgel, K, Wu, Y, Long, C, Wright, G, Lescano, A, Draper, S |
---|---|
Format: | Journal article |
Jezik: | English |
Izdano: |
Cell Press
2015
|
Slični predmeti
-
Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
od: Douglas, A, i dr.
Izdano: (2014) -
A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
od: Bustamante, L, i dr.
Izdano: (2013) -
Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
od: Williams, A, i dr.
Izdano: (2012) -
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
od: Douglas, A, i dr.
Izdano: (2011) -
Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies
od: Alanine, DGW
Izdano: (2017)