Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried ou...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1797061850152566784 |
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| author | Fullam, E Talbot, J Abuhammed, A Westwood, I Davies, S Russell, A Sim, E |
| author_facet | Fullam, E Talbot, J Abuhammed, A Westwood, I Davies, S Russell, A Sim, E |
| author_sort | Fullam, E |
| collection | OXFORD |
| description | The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis. |
| first_indexed | 2024-03-06T20:37:03Z |
| format | Journal article |
| id | oxford-uuid:32ff5ecb-f8fb-464d-9367-fb39c71a2df1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:37:03Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:32ff5ecb-f8fb-464d-9367-fb39c71a2df12022-03-26T13:17:30ZDesign, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:32ff5ecb-f8fb-464d-9367-fb39c71a2df1EnglishSymplectic Elements at Oxford2013Fullam, ETalbot, JAbuhammed, AWestwood, IDavies, SRussell, ASim, EThe synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried out previously and found to inhibit the growth of Mycobacterium tuberculosis. |
| spellingShingle | Fullam, E Talbot, J Abuhammed, A Westwood, I Davies, S Russell, A Sim, E Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title | Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title_full | Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title_fullStr | Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title_full_unstemmed | Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title_short | Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. |
| title_sort | design synthesis and structure activity relationships of 3 5 diaryl 1h pyrazoles as inhibitors of arylamine n acetyltransferase |
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