A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A sec...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797061851840774144 |
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| author | Tosh, K Meisner, S Siddiqui, MR Balakrishnan, K Ghei, S Golding, M Sengupta, U Pitchappan, R Hill, A |
| author_facet | Tosh, K Meisner, S Siddiqui, MR Balakrishnan, K Ghei, S Golding, M Sengupta, U Pitchappan, R Hill, A |
| author_sort | Tosh, K |
| collection | OXFORD |
| description | A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. |
| first_indexed | 2024-03-06T20:37:05Z |
| format | Journal article |
| id | oxford-uuid:33016afd-2d35-4e24-9215-814d727536b1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:37:05Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:33016afd-2d35-4e24-9215-814d727536b12022-03-26T13:17:39ZA region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:33016afd-2d35-4e24-9215-814d727536b1EnglishSymplectic Elements at Oxford2002Tosh, KMeisner, SSiddiqui, MRBalakrishnan, KGhei, SGolding, MSengupta, UPitchappan, RHill, AA major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. |
| spellingShingle | Tosh, K Meisner, S Siddiqui, MR Balakrishnan, K Ghei, S Golding, M Sengupta, U Pitchappan, R Hill, A A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title_full | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title_fullStr | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title_full_unstemmed | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title_short | A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. |
| title_sort | region of chromosome 20 is linked to leprosy susceptibility in a south indian population |
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